Institute of Applied Physics Nello Carrara, Italian National Research Council, via Madonna del Piano, 10-50019 Sesto Fiorentino, Italy.
J Biomed Opt. 2012 Jan;17(1):010701. doi: 10.1117/1.JBO.17.1.010701.
We report recent achievements and future perspectives of minimally invasive bonding of biological tissues triggered by laser light. In particular, we review new advancements in the biomedical exploitation of near-infrared absorbing gold nanoparticles as an original solution for the photothermal closure of surgical incisions. Advanced concepts of laser tissue bonding involving the application of hybrid nanocomposites obtained by inclusion of nanochromophores into biopolymer scaffolds are also introduced. The perspectives of tissue bonding are discussed in the following aspects: (1) tissue bonding with highly-stabilized nanochromophores, (2) enhanced tissue bonding with patterned nanocomposites, (3) real-time monitoring of temperature distributions, (4) tracking of tissue regeneration based on the optical resonances of gold nanoparticles.
我们报告了激光触发的微创生物组织结合的最新成果和未来展望。特别是，我们综述了近红外吸收金纳米粒子在作为手术切口光热闭合的原始解决方案的生物医学应用方面的新进展。我们还介绍了涉及将纳米发色团纳入生物聚合物支架中以获得混合纳米复合材料的激光组织结合的先进概念。从以下几个方面讨论了组织结合的前景：（1）具有高稳定性纳米发色团的组织结合，（2）具有图案化纳米复合材料的增强组织结合，（3）温度分布的实时监测，（4）基于金纳米粒子的光学共振的组织再生跟踪。
