Tomizawa Minoru, Shinozaki Fuminobu, Hasegawa Rumiko, Fugo Kazunori, Shirai Yoshinori, Motoyoshi Yasufumi, Sugiyama Takao, Yamamoto Shigenori, Kishimoto Takashi, Ishige Naoki
Department of Gastroenterology, National Hospital Organization Shimoshizu Hospital, Yotsukaido, Chiba 284-0003, Japan.
Department of Radiology, National Hospital Organization Shimoshizu Hospital, Yotsukaido, Chiba 284-0003, Japan.
Mol Clin Oncol. 2016 Jul;5(1):64-68. doi: 10.3892/mco.2016.903. Epub 2016 May 11.
Patient records were retrospectively analyzed to elucidate the characteristics of patients with colorectal cancer (CRC) diagnosed with screening abdominal ultrasound (US). Patients diagnosed with CRC using abdominal US [localized irregular wall thickening (W) or a hypoechoic mass with a hyperechoic mass (M)] were enrolled. The patients were subjected to colonoscopy and treated surgically between March, 2010 and January, 2015. A total of 5 men (aged 74.0±0.8 years) and 10 women (aged 73.0±12.0 years) were analyzed. Stratification was analyzed with abdominal US. The threshold value of wall thickness to diagnose CRC was investigated with receiver operating characteristic (ROC) curve analysis. The average wall thickness was 2.8±0.4 mm in the surrounding normal tissue and 12.7±5.2 mm in CRC (one-way analysis of variance, P<0.0001). The wall was significantly thicker in CRC compared with the normal colonic wall. The calculated threshold value was 4.3 mm for the diagnosis of CRC. Stratification was preserved in W, while it was lost in M (Chi-squared test, P=0.0196). The hemoglobin concentration was lower, while the C-reactive protein, carcinoembryonic antigen and carbohydrate antigen 19-9 levels were elevated above normal values. The threshold value was 4.3 mm for the diagnosis of CRC with abdominal US.
对患者记录进行回顾性分析，以阐明经腹部超声筛查诊断为结直肠癌（CRC）患者的特征。纳入经腹部超声诊断为CRC的患者[局限性不规则壁增厚（W）或低回声肿块伴高回声肿块（M）]。这些患者在2010年3月至2015年1月期间接受了结肠镜检查并接受手术治疗。共分析了5名男性（年龄74.0±0.8岁）和10名女性（年龄73.0±12.0岁）。采用腹部超声进行分层分析。通过受试者操作特征（ROC）曲线分析研究诊断CRC的壁厚度阈值。周围正常组织的平均壁厚度为2.8±0.4mm，CRC中的平均壁厚度为12.7±5.2mm（单因素方差分析，P<0.0001）。与正常结肠壁相比，CRC中的壁明显更厚。诊断CRC的计算阈值为4.3mm。在W中分层得以保留，而在M中分层消失（卡方检验，P=0.0196）。血红蛋白浓度较低，而C反应蛋白、癌胚抗原和糖类抗原19-9水平高于正常值。腹部超声诊断CRC的阈值为4.3mm。
