NKX6.3 是 Wnt/β-连环蛋白和 Rho-GTPase 信号相关基因的转录因子，可抑制胃癌进展。

NKX6.3 Is a Transcription Factor for Wnt/β-catenin and Rho-GTPase Signaling-Related Genes to Suppress Gastric Cancer Progression.

机构信息

Department of Pathology, College of Medicine, The Catholic University of Korea, 505 Banpo-dong, Seocho-gu, Seoul 137-701, South Korea.

Department of Pathology, College of Medicine, The Catholic University of Korea, 505 Banpo-dong, Seocho-gu, Seoul 137-701, South Korea; Functional RNomics Research Center, College of Medicine, The Catholic University of Korea, 505 Banpo-dong, Seocho-gu, Seoul 137-701, South Korea.

出版信息

EBioMedicine. 2016 Jul;9:97-109. doi: 10.1016/j.ebiom.2016.05.027. Epub 2016 May 25.

Despite ongoing research and recent progress, the prognosis for patients with advanced gastric cancer remains poor. Wnt/β-catenin and Rho-GTPase signaling pathways are known to play essential roles in malignant transformation and progression of various tumors, including gastric cancer. Here, we identify that NKX6 transcription factor, locus 3 (NKX6.3) binds directly to specific promoter regions of Wnt/β-catenin and Rho-GTPase pathway-related genes, resulting in inhibition of cancer cell migration and invasion. Additionally, we find that the expression level of NKX6.3 is involved in regulation of gastric cancer progression and expression of Wnt/β-catenin and Rho-GTPase pathway-related genes in clinical samples. These results suggest that NKX6.3 prevents EMT and cell migration, implying that NKX6.3 inactivation might be one of the key mechanisms of gastric cancer cell invasion and metastasis.

尽管不断有研究和最近的进展，但晚期胃癌患者的预后仍然不佳。Wnt/β-catenin 和 Rho-GTPase 信号通路已被证实对各种肿瘤的恶性转化和进展起着至关重要的作用，包括胃癌。在这里，我们发现 NKX6 转录因子，位点 3（NKX6.3）可直接与 Wnt/β-catenin 和 Rho-GTPase 通路相关基因的特定启动子区域结合，从而抑制癌细胞的迁移和侵袭。此外，我们发现 NKX6.3 的表达水平与胃癌的进展以及临床样本中 Wnt/β-catenin 和 Rho-GTPase 通路相关基因的表达有关。这些结果表明，NKX6.3 可阻止 EMT 和细胞迁移，这意味着 NKX6.3 的失活可能是胃癌细胞侵袭和转移的关键机制之一。