皮肤保护屏障水渗透的体外和体内评估
In vitro and in vivo evaluation of water penetration through skin protectant barriers.
作者信息
Shah S, Kirchner F
机构信息
ConvaTec, St. Louis, missouri, USA.
出版信息
Skin Res Technol. 1997 May;3(2):114-20. doi: 10.1111/j.1600-0846.1997.tb00172.x.
BACKGROUND/AIMS: To evaluate moisture penetration through thin films of skin protectants both in vivo and in vitro.
METHODS
Fourier transform infrared (FTIR) spectroscopy was used in the reflectance mode. The in vivo studies involved moisture penetration through skin in the absence and presence of thin skin protectant films on the forearm. Moisture penetration through the stratum corneum was monitored by peeling layers of stratum corneum with Scotch(tm) tape. The in vitro studies involved the use of a 1 mm thick film of the skin protectant products on the window of the attenuated total reflectance (ATR) cell. The moisture penetration in both cases was determined by monitoring the water band at 3300 cm(-1) . The two products evaluated were petrolatum and iLEX®.
RESULTS/CONCLUSIONS: Both the in vivo and in vitro results suggest that FTIR reflectance spectroscopy can be used to determine moisture penetration through skin protectant barrier films.
背景/目的：在体内和体外评估皮肤保护剂薄膜的透湿性。
方法
采用反射模式的傅里叶变换红外（FTIR）光谱法。体内研究包括在前臂皮肤不存在和存在薄皮肤保护剂薄膜的情况下监测透湿性。通过用思高（Scotch）胶带逐层剥离角质层来监测角质层的透湿性。体外研究包括在衰减全反射（ATR）池窗口上使用1毫米厚的皮肤保护剂产品薄膜。两种情况下的透湿性均通过监测3300 cm⁻¹处的水带来确定。评估的两种产品是凡士林和iLEX®。
结果/结论：体内和体外结果均表明，FTIR反射光谱法可用于测定通过皮肤保护屏障膜的透湿性。
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