Pariente Gali, Kessous Roy, Sergienko Ruslan, Sheiner Eyal
a Department of Obstetrics and Gynecology , Faculty of Health Sciences, Soroka University Medical Center, Ben-Gurion University of the Negev , Beer-Sheva , Israel and.
b Department of Epidemiology and Health Services Evaluation , Ben-Gurion University of the Negev , Beer-Sheva , Israel.
J Matern Fetal Neonatal Med. 2017 May;30(9):1102-1107. doi: 10.1080/14767058.2016.1205022. Epub 2016 Jul 13.
To investigate whether women who had a preterm delivery (PTD) are at an increased risk of subsequent long term maternal kidney disease.
A population-based study compared the incidence of long-term maternal kidney disease in a cohort of women with and without previous PTD. Deliveries occurred during a 25 years period, with a mean follow-up duration of 11.2 years.
Of 99 338 deliveries of women, 16 364 (16.4%) occurred in patients who had at least one PTD. A significant dose response was found between the number of previous PTDs and the gestational age at birth of the PTDs and future risk for renal-related hospitalizations. Patients with either spontaneous or indicated PTD had higher rates of renal-related hospitalizations (0.2% versus 0.1% OR= 2.6; 95%CI: 1.7-3.9, p <0.001 and 0.5% versus 0.2% OR 3.41; 95%CI: 1.7-6.5, p < 0.001, respectively). In a Cox proportional hazards model, PTD was independently associated with long-term maternal renal-related hospitalizations.
PTD is an independent risk factor for long-term maternal kidney disease.
研究早产女性后续发生长期母体肾脏疾病的风险是否增加。
一项基于人群的研究比较了有早产史和无早产史女性队列中母体长期肾脏疾病的发病率。分娩发生在25年期间，平均随访时间为11.2年。
在99338例女性分娩中，16364例（16.4%）发生在至少有一次早产的患者中。既往早产次数与早产时的出生孕周以及未来肾脏相关住院风险之间存在显著的剂量反应关系。自发性早产或指征性早产患者的肾脏相关住院率更高（分别为0.2%对0.1%，OR = 2.6；95%CI：1.7 - 3.9，p < 0.001；以及0.5%对0.2%，OR = 3.41；95%CI：1.7 - 6.5，p < 0.001）。在Cox比例风险模型中，早产与母体长期肾脏相关住院独立相关。
早产是母体长期肾脏疾病的独立危险因素。
