• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

兔心室肌细胞电生理的特异性计算模型：利用模型群体探索缺血反应的变异性。

Rabbit-specific computational modelling of ventricular cell electrophysiology: Using populations of models to explore variability in the response to ischemia.

作者信息

Gemmell Philip, Burrage Kevin, Rodríguez Blanca, Quinn T Alexander

机构信息

Department of Computer Science, University of Oxford, Oxford, UK.

Department of Computer Science, University of Oxford, Oxford, UK; School of Mathematical Sciences and ARC Centre of Excellence, ACEMS, Queensland University of Technology, Brisbane, Australia.

出版信息

Prog Biophys Mol Biol. 2016 Jul;121(2):169-84. doi: 10.1016/j.pbiomolbio.2016.06.003. Epub 2016 Jun 16.

DOI:10.1016/j.pbiomolbio.2016.06.003
PMID:27320382
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5405055/
Abstract

Computational modelling, combined with experimental investigations, is a powerful method for investigating complex cardiac electrophysiological behaviour. The use of rabbit-specific models, due to the similarities of cardiac electrophysiology in this species with human, is especially prevalent. In this paper, we first briefly review rabbit-specific computational modelling of ventricular cell electrophysiology, multi-cellular simulations including cellular heterogeneity, and acute ischemia. This mini-review is followed by an original computational investigation of variability in the electrophysiological response of two experimentally-calibrated populations of rabbit-specific ventricular myocyte action potential models to acute ischemia. We performed a systematic exploration of the response of the model populations to varying degrees of ischemia and individual ischemic parameters, to investigate their individual and combined effects on action potential duration and refractoriness. This revealed complex interactions between model population variability and ischemic factors, which combined to enhance variability during ischemia. This represents an important step towards an improved understanding of the role that physiological variability may play in electrophysiological alterations during acute ischemia.

摘要

计算建模与实验研究相结合，是研究复杂心脏电生理行为的有力方法。由于该物种心脏电生理与人类相似，使用兔特异性模型尤为普遍。在本文中，我们首先简要回顾了兔特异性心室细胞电生理的计算建模、包括细胞异质性的多细胞模拟以及急性缺血。本小型综述之后是一项原创性计算研究，研究了两个经过实验校准的兔特异性心室肌细胞动作电位模型群体对急性缺血的电生理反应变异性。我们对模型群体对不同程度缺血和个体缺血参数的反应进行了系统探索，以研究它们对动作电位持续时间和不应期的个体和联合影响。这揭示了模型群体变异性与缺血因素之间的复杂相互作用，这些相互作用共同增强了缺血期间的变异性。这代表了朝着更好地理解生理变异性在急性缺血期间电生理改变中可能发挥的作用迈出的重要一步。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ebc5/5405055/4d2a241b3eca/gr7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ebc5/5405055/78b8392e2b63/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ebc5/5405055/710501d9c3b1/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ebc5/5405055/84975d8825a2/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ebc5/5405055/7de23fd90512/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ebc5/5405055/a8f7501eb64b/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ebc5/5405055/480eacdfe949/gr6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ebc5/5405055/4d2a241b3eca/gr7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ebc5/5405055/78b8392e2b63/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ebc5/5405055/710501d9c3b1/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ebc5/5405055/84975d8825a2/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ebc5/5405055/7de23fd90512/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ebc5/5405055/a8f7501eb64b/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ebc5/5405055/480eacdfe949/gr6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ebc5/5405055/4d2a241b3eca/gr7.jpg

相似文献

1
Rabbit-specific computational modelling of ventricular cell electrophysiology: Using populations of models to explore variability in the response to ischemia.兔心室肌细胞电生理的特异性计算模型：利用模型群体探索缺血反应的变异性。
Prog Biophys Mol Biol. 2016 Jul;121(2):169-84. doi: 10.1016/j.pbiomolbio.2016.06.003. Epub 2016 Jun 16.
2
Electrophysiological properties of computational human ventricular cell action potential models under acute ischemic conditions.急性缺血条件下计算型人类心室肌细胞动作电位模型的电生理特性
Prog Biophys Mol Biol. 2017 Oct;129:40-52. doi: 10.1016/j.pbiomolbio.2017.02.007. Epub 2017 Feb 20.
3
Population of computational rabbit-specific ventricular action potential models for investigating sources of variability in cellular repolarisation.用于研究细胞复极化变异性来源的计算兔特异性心室动作电位模型群体。
PLoS One. 2014 Feb 28;9(2):e90112. doi: 10.1371/journal.pone.0090112. eCollection 2014.
4
Computational rabbit models to investigate the initiation, perpetuation, and termination of ventricular arrhythmia.用于研究室性心律失常的起始、持续和终止的计算兔模型。
Prog Biophys Mol Biol. 2016 Jul;121(2):185-94. doi: 10.1016/j.pbiomolbio.2016.06.004. Epub 2016 Jun 19.
5
Modeling transmural heterogeneity of K(ATP) current in rabbit ventricular myocytes.兔心室肌细胞中K(ATP)电流跨壁异质性的建模
Am J Physiol Cell Physiol. 2007 Aug;293(2):C542-57. doi: 10.1152/ajpcell.00148.2006. Epub 2007 Feb 28.
6
Variability in cardiac electrophysiology: Using experimentally-calibrated populations of models to move beyond the single virtual physiological human paradigm.心脏电生理学的变异性：使用经过实验校准的模型群体超越单一虚拟生理人类范式。
Prog Biophys Mol Biol. 2016 Jan;120(1-3):115-27. doi: 10.1016/j.pbiomolbio.2015.12.002. Epub 2015 Dec 14.
7
In-silico human electro-mechanical ventricular modelling and simulation for drug-induced pro-arrhythmia and inotropic risk assessment.基于计算机的人心室机电建模与仿真在药物致心律失常和变力性风险评估中的应用。
Prog Biophys Mol Biol. 2021 Jan;159:58-74. doi: 10.1016/j.pbiomolbio.2020.06.007. Epub 2020 Jul 22.
8
Myocardial ischemia simulation based on a multi-scale heart electrophysiology model.基于多尺度心脏电生理学模型的心肌缺血模拟。
Technol Health Care. 2024;32(S1):27-38. doi: 10.3233/THC-248003.
9
Differences in the electrophysiological response of canine ventricular epicardium and endocardium to ischemia. Role of the transient outward current.犬心室心外膜和心内膜对缺血电生理反应的差异。瞬时外向电流的作用。
Circulation. 1993 Dec;88(6):2903-15. doi: 10.1161/01.cir.88.6.2903.
10
Development, calibration, and validation of a novel human ventricular myocyte model in health, disease, and drug block.新型健康、疾病和药物阻滞人心室肌细胞模型的开发、校准和验证。
Elife. 2019 Dec 24;8:e48890. doi: 10.7554/eLife.48890.

引用本文的文献

1
Relationship between ion currents and membrane capacitance in canine ventricular myocytes.犬心室肌细胞离子流与膜电容的关系。
Sci Rep. 2024 May 16;14(1):11241. doi: 10.1038/s41598-024-61736-6.
2
Neural network emulation of the human ventricular cardiomyocyte action potential for more efficient computations in pharmacological studies.神经网络模拟人类心室肌细胞动作电位，以提高药理学研究中的计算效率。
Elife. 2024 Apr 10;12:RP91911. doi: 10.7554/eLife.91911.
3
Neural network emulation of the human ventricular cardiomyocyte action potential: a tool for more efficient computation in pharmacological studies.

本文引用的文献

1
Sampling methods for exploring between-subject variability in cardiac electrophysiology experiments.用于探索心脏电生理实验中个体间变异性的抽样方法。
J R Soc Interface. 2016 Aug;13(121). doi: 10.1098/rsif.2016.0214.
2
Computational rabbit models to investigate the initiation, perpetuation, and termination of ventricular arrhythmia.用于研究室性心律失常的起始、持续和终止的计算兔模型。
Prog Biophys Mol Biol. 2016 Jul;121(2):185-94. doi: 10.1016/j.pbiomolbio.2016.06.004. Epub 2016 Jun 19.
3
Electron tomography of rabbit cardiomyocyte three-dimensional ultrastructure.
人类心室心肌细胞动作电位的神经网络模拟：药理学研究中更高效计算的工具。
bioRxiv. 2023 Dec 25:2023.08.16.553497. doi: 10.1101/2023.08.16.553497.
4
The importance of mechanical conditions in the testing of excitation abnormalities in a population of electro-mechanical models of human ventricular cardiomyocytes.机械条件在一群人心室心肌细胞的机电模型中激发异常测试中的重要性。
Front Physiol. 2023 Jun 8;14:1187956. doi: 10.3389/fphys.2023.1187956. eCollection 2023.
5
Electrophysiological heterogeneity in large populations of rabbit ventricular cardiomyocytes.兔心室心肌细胞大群体中的电生理异质性。
Cardiovasc Res. 2022 Dec 9;118(15):3112-3125. doi: 10.1093/cvr/cvab375.
6
Three-Week-Old Rabbit Ventricular Cardiomyocytes as a Novel System to Study Cardiac Excitation and EC Coupling.三周龄兔心室心肌细胞作为研究心脏兴奋和兴奋-收缩偶联的新型系统。
Front Physiol. 2021 Nov 18;12:672360. doi: 10.3389/fphys.2021.672360. eCollection 2021.
7
Mechano-Electric Coupling and Arrhythmogenic Current Generation in a Computational Model of Coupled Myocytes.耦合心肌细胞计算模型中的机电耦合与致心律失常电流产生
Front Physiol. 2020 Dec 10;11:519951. doi: 10.3389/fphys.2020.519951. eCollection 2020.
8
Sensitivity of a data-assimilation system for reconstructing three-dimensional cardiac electrical dynamics.三维心脏电动力学重构数据同化系统的敏感性。
Philos Trans A Math Phys Eng Sci. 2020 Jun 12;378(2173):20190388. doi: 10.1098/rsta.2019.0388. Epub 2020 May 25.
9
Variability in electrophysiological properties and conducting obstacles controls re-entry risk in heterogeneous ischaemic tissue.电生理特性和传导障碍的变异性控制着非均质性缺血组织中的折返风险。
Philos Trans A Math Phys Eng Sci. 2020 Jun 12;378(2173):20190341. doi: 10.1098/rsta.2019.0341. Epub 2020 May 25.
10
High arrhythmic risk in antero-septal acute myocardial ischemia is explained by increased transmural reentry occurrence.前间隔急性心肌缺血的高心律失常风险是由穿壁折返的发生增加所解释的。
Sci Rep. 2019 Nov 14;9(1):16803. doi: 10.1038/s41598-019-53221-2.
兔心肌细胞三维超微结构的电子断层扫描
Prog Biophys Mol Biol. 2016 Jul;121(2):77-84. doi: 10.1016/j.pbiomolbio.2016.05.005. Epub 2016 May 19.
4
Uncertainty and variability in computational and mathematical models of cardiac physiology.心脏生理学计算和数学模型中的不确定性与变异性。
J Physiol. 2016 Dec 1;594(23):6833-6847. doi: 10.1113/JP271671. Epub 2016 Jun 9.
5
Multiscale Modeling in the Clinic: Drug Design and Development.临床中的多尺度建模：药物设计与开发
Ann Biomed Eng. 2016 Sep;44(9):2591-610. doi: 10.1007/s10439-016-1563-0. Epub 2016 Feb 17.
6
Early afterdepolarizations promote transmural reentry in ischemic human ventricles with reduced repolarization reserve.早期后去极化促进复极储备降低的缺血性人类心室的透壁折返。
Prog Biophys Mol Biol. 2016 Jan;120(1-3):236-48. doi: 10.1016/j.pbiomolbio.2016.01.008. Epub 2016 Feb 2.
7
Modeling our understanding of the His-Purkinje system.构建我们对希氏-浦肯野系统的理解模型。
Prog Biophys Mol Biol. 2016 Jan;120(1-3):179-88. doi: 10.1016/j.pbiomolbio.2015.12.013. Epub 2015 Dec 29.
8
Cell-specific Dynamic Clamp analysis of the role of funny If current in cardiac pacemaking.心脏起搏中If电流作用的细胞特异性动态钳分析
Prog Biophys Mol Biol. 2016 Jan;120(1-3):50-66. doi: 10.1016/j.pbiomolbio.2015.12.004. Epub 2015 Dec 21.
9
Variability in cardiac electrophysiology: Using experimentally-calibrated populations of models to move beyond the single virtual physiological human paradigm.心脏电生理学的变异性：使用经过实验校准的模型群体超越单一虚拟生理人类范式。
Prog Biophys Mol Biol. 2016 Jan;120(1-3):115-27. doi: 10.1016/j.pbiomolbio.2015.12.002. Epub 2015 Dec 14.
10
Improving cardiomyocyte model fidelity and utility via dynamic electrophysiology protocols and optimization algorithms.通过动态电生理协议和优化算法提高心肌细胞模型的逼真度和实用性。
J Physiol. 2016 May 1;594(9):2525-36. doi: 10.1113/JP270618. Epub 2016 Feb 4.