内皮细胞之间的紧密连接：纳米颗粒与血管之间的相互作用。
Tight junction between endothelial cells: the interaction between nanoparticles and blood vessels.
作者信息
Zhang Yue, Yang Wan-Xi
机构信息
The Sperm Laboratory, College of Life Sciences, Zhejiang University, Hangzhou 310058, PR China.
出版信息
Beilstein J Nanotechnol. 2016 May 6;7:675-84. doi: 10.3762/bjnano.7.60. eCollection 2016.
Abstract
Since nanoparticles are now widely applied as food additives, in cosmetics and other industries, especially in medical therapy and diagnosis, we ask here whether nanoparticles can cause several adverse effects to human health. In this review, based on research on nanotoxicity, we mainly discuss the negative influence of nanoparticles on blood vessels in several aspects and the potential mechanism for nanoparticles to penetrate endothelial layers of blood vessels, which are the sites of phosphorylation of tight junction proteins (claudins, occludins, and ZO (Zonula occludens)) proteins, oxidative stress and shear stress. We propose a connection between the presence of nanoparticles and the regulation of the tight junction, which might be the key approach for nanoparticles to penetrate endothelial layers and then have an impact on other tissues and organs.
摘要
由于纳米颗粒目前被广泛应用于食品添加剂、化妆品及其他行业，尤其是医学治疗和诊断领域，我们在此探讨纳米颗粒是否会对人体健康造成多种不良影响。在本综述中，基于对纳米毒性的研究，我们主要从几个方面讨论纳米颗粒对血管的负面影响，以及纳米颗粒穿透血管内皮细胞层的潜在机制，这些内皮细胞层是紧密连接蛋白（闭合蛋白、封闭蛋白和闭锁小带蛋白）磷酸化、氧化应激和剪切应力的发生部位。我们提出纳米颗粒的存在与紧密连接调节之间存在联系，这可能是纳米颗粒穿透内皮细胞层进而影响其他组织和器官的关键途径。
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