恩杂鲁胺单药治疗对前列腺癌多参数3T磁共振成像的影响
The Effects of Enzalutamide Monotherapy on Multiparametric 3T MR Imaging in Prostate Cancer.
作者信息
Van der Roest Rosanne Cv, van Houdt Petra J, Heijmink Stijn Wtpj, de Jong Jeroen, Bergman André M, Zwart Wilbert, van der Heide Uulke A, van der Poel Henk G
机构信息
Department of Urology, The Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands.
Department of Radiotherapy, The Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands.
出版信息
Urol Case Rep. 2016 May 26;7:67-9. doi: 10.1016/j.eucr.2016.04.010. eCollection 2016 Jul.
The effects of enzalutamide monotherapy on prostate tumor downsizing and multiparametric MRI are currently unknown. Here we present the first case in literature of a patient with high-grade prostate cancer who underwent 3 months of neoadjuvant enzalutamide, for which the effects on mpMRI and histology were determined. Tumor size reduction and downstaging were noted. Neoadjuvant enzalutamide resulted in an increase in ADC value on the DWI-MRI sequences. Histological changes were also observed.
恩杂鲁胺单药治疗对前列腺肿瘤缩小及多参数磁共振成像的影响目前尚不清楚。在此，我们报告文献中首例接受3个月新辅助恩杂鲁胺治疗的高级别前列腺癌患者，确定了其对多参数磁共振成像和组织学的影响。观察到肿瘤大小缩小和分期降低。新辅助恩杂鲁胺导致扩散加权成像磁共振序列上的表观扩散系数值增加。还观察到了组织学变化。
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