Suursalmi Piia, Korhonen Päivi, Kopeli Tarja, Nieminen Riina, Luukkaala Tiina, Moilanen Eeva, Tammela Outi
Tampere University Hospital, Tampere, Finland; University of Tampere, Tampere, Finland.
Päijät-Häme Central Hospital, Lahti, Finland.
Glob Pediatr Health. 2016 Mar 16;3:2333794X16637290. doi: 10.1177/2333794X16637290. eCollection 2016.
This study evaluated nutrition and growth in relation to plasma adipokine levels in 21 very-low-birth-weight (VLBW) children with radiographic bronchopulmonary dysplasia (BPD), 19 VLBW controls, and 19 term controls with a median age of 11.3 years. We took anthropometric measurements; assessed plasma levels of adipsin, resistin, adiponectin, and leptin; and analyzed the children's 3-day food records. Children with BPD had a smaller age-adjusted head circumference and more microcephaly but no other significant growth differences. Daily recommended nutritional intake levels were poorly met but did not differ between the groups. Leptin levels correlated positively with the body mass index standard deviation score in VLBW children. No other associations between adipokine concentrations and growth were found. There were negative correlations between leptin concentrations and fat intake, resistin levels and carbohydrate intake, and adiponectin, adipsin, and leptin levels and energy intake.
本研究评估了21名患有放射性支气管肺发育不良（BPD）的极低出生体重（VLBW）儿童、19名VLBW对照儿童和19名足月对照儿童（中位年龄11.3岁）的营养和生长情况与血浆脂肪因子水平的关系。我们进行了人体测量；评估了血浆中脂联素、抵抗素、脂联素和瘦素的水平；并分析了儿童的3天食物记录。患有BPD的儿童年龄校正后的头围较小且小头畸形较多，但无其他显著的生长差异。每日推荐营养摄入量水平未得到充分满足，但各组之间无差异。在VLBW儿童中，瘦素水平与体重指数标准差评分呈正相关。未发现脂肪因子浓度与生长之间的其他关联。瘦素浓度与脂肪摄入量、抵抗素水平与碳水化合物摄入量、脂联素、脂联素和瘦素水平与能量摄入量之间存在负相关。
