Bôas Huguenin Grazielle Vilas, Kimi Uehara Sofia, Nogueira Netto José Firmino, Gaspar de Moura Egberto, Rosa Glorimar, da Fonseca Passos Magna Cottini
Department of Dietetics and Nutrition. Federal University of Rio de Janeiro. Rio de Janeiro. RJ. Brazil..
Department of Physiological Sciences. Biology Institute. State University of Rio de Janeiro. Rio de Janeiro. RJ. Brazil..
Nutr Hosp. 2014 Jul 1;30(1):53-9. doi: 10.3305/nh.2014.30.1.7464.
Obesity and insulin resistance are associated with an increase of cardiovascular risk factors, including adipocytokines. The aim of this study was to investigate the effect of low-calorie diet on serum lipids, adipokines, insulin resistance and body composition in obese women. It was a clinical trial with class I obese women aged 30-45 years submitted to hypocaloric diet for 90 days. Dietary intake, anthropometric parameters, body composition, serum lipids, glucose, insulin, leptin, adiponectin, HOMA-IR and QUICKI indexes were evaluated at the baseline, 30, 60 and 90 days. There was 30% significant decrease in energy intake, and also decrease in body weight, body mass index and waist circumference (p < 0.01) throughout the treatment period. Despite the amount of lean body mass (kg) reduced in average, it was observed that lean body mass (%) had increased (p < 0.01) and that the amount of fat body mass (kg) had decreased significantly in the third month (p < 0.05). Systolic blood pressure reduced up to -5mmHg (p < 0.05) after 90 days. Was observed a decrease (p < 0.05) on serum insulin and HOMA-IR until the 60th day, while the serum adiponectin increased (p < 0.01) during treatment. Corroborating with the reduction of fat body mass and weight, serum leptin also reduced (p < 0.01). These results suggest that the short-term low-calorie diet reduces total body fat, mainly found in the abdominal region, and efficiently improve insulin sensitivity decreasing cardiovascular risk in obese women.
肥胖和胰岛素抵抗与包括脂肪细胞因子在内的心血管危险因素增加有关。本研究的目的是调查低热量饮食对肥胖女性血清脂质、脂肪细胞因子、胰岛素抵抗和身体成分的影响。这是一项针对30至45岁I级肥胖女性的临床试验，她们接受了90天的低热量饮食。在基线、第30、60和90天评估饮食摄入量、人体测量参数、身体成分、血清脂质、葡萄糖、胰岛素、瘦素、脂联素、HOMA-IR和QUICKI指数。在整个治疗期间，能量摄入显著减少30%，体重、体重指数和腰围也有所下降（p<0.01）。尽管瘦体重（kg）平均减少，但观察到瘦体重（%）增加（p<0.01），并且在第三个月时脂肪体重（kg）显著减少（p<0.05）。90天后收缩压降低了-5mmHg（p<0.05）。直到第60天，血清胰岛素和HOMA-IR均下降（p<0.05），而在治疗期间血清脂联素增加（p<0.01）。与脂肪体重和体重的减少相一致，血清瘦素也降低了（p<0.01）。这些结果表明，短期低热量饮食可减少全身脂肪，主要是腹部脂肪，并有效改善胰岛素敏感性，降低肥胖女性的心血管风险。
