西洛芬净（LY 121019）与两性霉素B或氟胞嘧啶联合使用对念珠菌属的作用。

The effect of cilofungin (LY 121019) in combination with amphotericin B or flucytosine against Candida species.

作者信息

Bulo A N, Bradley S F, Kauffman C A

出版信息

Mycoses. 1989 Mar;32(3):151-7. doi: 10.1111/j.1439-0507.1989.tb02224.x.

DOI:10.1111/j.1439-0507.1989.tb02224.x

Abstract

Cilofungin was combined with amphotericin B or flucytosine to determine if synergistic inhibition or killing occurred against 50 strains of various Candida species. Synergistic inhibition of growth occurred only once with amphotericin B and cilofungin and only 2 times with flucytosine and cilofungin. Synergistic killing occurred in 5 strains with the amphotericin B-cilofungin combination and in 7 strains with the flucytosine-cilofungin combination. Antagonism occurred frequently with both the amphotericin B-cilofungin and the flucytosine-cilofungin combinations.

摘要

将西洛芬净与两性霉素B或氟胞嘧啶联合使用，以确定对50株不同念珠菌属菌株是否产生协同抑制或杀伤作用。两性霉素B与西洛芬净联合使用时仅出现过1次生长协同抑制，氟胞嘧啶与西洛芬净联合使用时仅出现过2次生长协同抑制。两性霉素B-西洛芬净联合使用时在5株菌株中出现协同杀伤作用，氟胞嘧啶-西洛芬净联合使用时在7株菌株中出现协同杀伤作用。两性霉素B-西洛芬净组合和氟胞嘧啶-西洛芬净组合均频繁出现拮抗作用。