Smith K R, Lank K M, Dismukes W E, Cobbs C G
Department of Medicine, University of Alabama, Birmingham 35294.
Eur J Clin Microbiol Infect Dis. 1991 Jul;10(7):588-92. doi: 10.1007/BF01967280.
Cilofungin, a lipopeptide antifungal agent, was tested for in vitro activity alone and in combination with ketoconazole, itraconazole, flucytosine and amphotericin B against 102 clinical isolates of Candida species. At 48 hours all isolates of Candida albicans, Candida tropicalis, Candida paratropicalis and Candida glabrata were inhibited by less than or equal to 5 meg/ml of cilofungin. In contrast, the MIC90 for Candida krusei was 10 mcg/ml and for Candida parapsilosis greater than 40 mcg/ml. The interaction of combinations of cilofungin with amphotericin B, itraconazole, ketoconazole and flucytosine was additive or indifferent at 48 hours for 100%, 88%, 78% and 70% of all Candida species isolates, respectively. Overall, cilofungin demonstrated good activity in vitro against most Candida species isolates.
西洛芬净是一种脂肽类抗真菌药物，我们对其单独以及与酮康唑、伊曲康唑、氟胞嘧啶和两性霉素B联合使用时针对102株念珠菌属临床分离株的体外活性进行了测试。48小时时，所有白色念珠菌、热带念珠菌、副热带念珠菌和光滑念珠菌分离株均被小于或等于5微克/毫升的西洛芬净所抑制。相比之下，克柔念珠菌的MIC90为10微克/毫升，近平滑念珠菌的MIC90大于40微克/毫升。西洛芬净与两性霉素B、伊曲康唑、酮康唑和氟胞嘧啶联合使用时，分别对所有念珠菌属分离株的100%、88%、78%和70%在48小时时呈现相加作用或无相互作用。总体而言，西洛芬净在体外对大多数念珠菌属分离株显示出良好的活性。
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