Immunology Section, Department of Pathology and Diagnostics, University of Verona, 37135, Verona, Italy.
Microbiol Spectr. 2016 Jun;4(3). doi: 10.1128/microbiolspec.MCHD-0016-2015.
Myeloid-derived suppressor cells (MDSCs) represent a heterogeneous, immune-suppressive leukocyte population that develops systemically and infiltrates tumors. MDSCs can restrain the immune response through different mechanisms including essential metabolite consumption, reactive oxygen and nitrogen species production, as well as display of inhibitory surface molecules that alter T-cell trafficking and viability. Moreover, MDSCs play a role in tumor progression, acting directly on tumor cells and promoting cancer stemness, angiogenesis, stroma deposition, epithelial-to-mesenchymal transition, and metastasis formation. Many biological and pharmaceutical drugs affect MDSC expansion and functions in preclinical tumor models and patients, often reversing host immune dysfunctions and allowing a more effective tumor immunotherapy.
髓系来源的抑制性细胞（MDSCs）是一种异质性的、免疫抑制性的白细胞群体，它在全身发育并浸润肿瘤。MDSCs 可以通过不同的机制抑制免疫反应，包括消耗必需代谢物、产生活性氧和氮物种，以及表达抑制性表面分子，改变 T 细胞的迁移和活力。此外，MDSCs 在肿瘤进展中发挥作用，直接作用于肿瘤细胞，促进癌症干性、血管生成、基质沉积、上皮间质转化和转移形成。许多生物和药物在临床前肿瘤模型和患者中影响 MDSC 的扩增和功能，通常逆转宿主免疫功能障碍，使肿瘤免疫治疗更有效。
