免疫代谢——更好理解过敏性病理学及改善过敏性疾病治疗的契机？ - Suppr

Suppr

超能文献

Immune Metabolism-An Opportunity to Better Understand Allergic Pathology and Improve Treatment of Allergic Diseases?

作者信息

Goretzki Alexandra, Zimmermann Jennifer, Lin Yen-Ju, Schülke Stefan

机构信息

Molecular Allergology, Paul-Ehrlich-Institut, Langen, Germany.

出版信息

Front Allergy. 2022 Mar 9;3:825931. doi: 10.3389/falgy.2022.825931. eCollection 2022.

DOI:10.3389/falgy.2022.825931

PMID:35386646

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8974690/

Abstract

摘要

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a000/8974690/ca9141198f2e/falgy-03-825931-g0001.jpg

相似文献

Immune Metabolism-An Opportunity to Better Understand Allergic Pathology and Improve Treatment of Allergic Diseases?免疫代谢——更好理解过敏性病理学及改善过敏性疾病治疗的契机？

Front Allergy. 2022 Mar 9;3:825931. doi: 10.3389/falgy.2022.825931. eCollection 2022.

Immune metabolism in allergies, does it matter?-A review of immune metabolic basics and adaptations associated with the activation of innate immune cells in allergy.过敏中的免疫代谢：重要吗？——一篇综述过敏中固有免疫细胞激活相关的免疫代谢基础和适应性。

Allergy. 2021 Nov;76(11):3314-3331. doi: 10.1111/all.14843. Epub 2021 May 6.

Immune Metabolism of IL-4-Activated B Cells and Th2 Cells in the Context of Allergic Diseases.IL-4 激活的 B 细胞和 Th2 细胞在过敏性疾病中的免疫代谢。

Front Immunol. 2021 Dec 1;12:790658. doi: 10.3389/fimmu.2021.790658. eCollection 2021.

The Importance of Metabolism for Immune Homeostasis in Allergic Diseases.代谢对于过敏性疾病中免疫稳态的重要性。

Front Immunol. 2021 Jul 28;12:692004. doi: 10.3389/fimmu.2021.692004. eCollection 2021.

Mediators of the homeostasis and effector functions of memory Th2 cells as novel drug targets in intractable chronic allergic diseases.记忆性 Th2 细胞的稳态和效应功能的介质作为难治性慢性过敏性疾病的新型药物靶点。

Arch Pharm Res. 2019 Sep;42(9):754-765. doi: 10.1007/s12272-019-01159-4. Epub 2019 May 2.

Advances and novel developments in mechanisms of allergic inflammation.过敏性炎症机制的进展与新进展

Allergy. 2020 Dec;75(12):3100-3111. doi: 10.1111/all.14632. Epub 2020 Nov 4.

Immunomodulation: the future cure for allergic diseases.免疫调节：过敏性疾病的未来疗法。

Ann N Y Acad Sci. 2006 Nov;1088:100-15. doi: 10.1196/annals.1366.026.

Effects of Fatty Acid Oxidation and Its Regulation on Dendritic Cell-Mediated Immune Responses in Allergies: An Immunometabolism Perspective.脂肪酸氧化及其对过敏中树突状细胞介导免疫应答的调节作用：免疫代谢观点。

J Immunol Res. 2021 Aug 11;2021:7483865. doi: 10.1155/2021/7483865. eCollection 2021.

Immunometabolism in Tuberculosis.结核病中的免疫代谢

Front Immunol. 2016 Apr 21;7:150. doi: 10.3389/fimmu.2016.00150. eCollection 2016.

The effects of pollutants on the allergic immune response.污染物对过敏性免疫反应的影响。

Toxicology. 2000 Nov 2;152(1-3):3-12. doi: 10.1016/s0300-483x(00)00286-9.

引用本文的文献

Distinct maturation, glucose metabolism, and inflammatory function of human monocytes-derived IDECs mediated by anti-IgE and Pam3CSK4 alone or in combination.单独或联合使用抗IgE和Pam3CSK4介导的人单核细胞衍生的IDECs的不同成熟、葡萄糖代谢和炎症功能。

Front Immunol. 2024 Jul 17;15:1403263. doi: 10.3389/fimmu.2024.1403263. eCollection 2024.

The Plight of the Metabolite: Oxidative Stress and Tear Film Destabilisation Evident in Ocular Allergy Sufferers across Seasons in Victoria, Australia.代谢物的困境：澳大利亚维多利亚州季节性过敏性眼病患者的氧化应激和泪膜不稳定性。

Int J Mol Sci. 2024 Apr 4;25(7):4019. doi: 10.3390/ijms25074019.

Allergy-associated biomarkers in early life identified by Omics techniques.通过组学技术鉴定的生命早期与过敏相关的生物标志物。

Front Allergy. 2024 Feb 23;5:1359142. doi: 10.3389/falgy.2024.1359142. eCollection 2024.

Chronic allergy signaling: is it all stressed-out mitochondria?慢性过敏信号传导：一切都源于线粒体过度紧张吗？

Fac Rev. 2022 Dec 15;11:37. doi: 10.12703/r/11-37. eCollection 2022.

Role of Glycolysis and Fatty Acid Synthesis in the Activation and T Cell-Modulating Potential of Dendritic Cells Stimulated with a TLR5-Ligand Allergen Fusion Protein.TLR5 配体过敏原融合蛋白刺激的树突状细胞中糖酵解和脂肪酸合成的作用及其对 T 细胞的调节作用。

Int J Mol Sci. 2022 Oct 21;23(20):12695. doi: 10.3390/ijms232012695.

Modulation of dendritic cell metabolism by an MPLA-adjuvanted allergen product for specific immunotherapy.一种 MPLA 佐剂变应原产物对树突状细胞代谢的调节及其在特异性免疫治疗中的作用。

Front Immunol. 2022 Aug 17;13:916491. doi: 10.3389/fimmu.2022.916491. eCollection 2022.

本文引用的文献

Peroxisomal Fatty Acid Oxidation and Glycolysis Are Triggered in Mouse Models of Lesional Atopic Dermatitis.在损伤性特应性皮炎小鼠模型中，过氧化物酶体脂肪酸氧化和糖酵解被触发。

JID Innov. 2021 Jun 15;1(3):100033. doi: 10.1016/j.xjidi.2021.100033. eCollection 2021 Sep.

Targeting cancer metabolism in the era of precision oncology.精准肿瘤学时代的肿瘤代谢靶向治疗。

Nat Rev Drug Discov. 2022 Feb;21(2):141-162. doi: 10.1038/s41573-021-00339-6. Epub 2021 Dec 3.

Irg1/itaconate metabolic pathway is a crucial determinant of dendritic cells immune-priming function and contributes to resolute allergen-induced airway inflammation.Irg1/itaconate 代谢途径是树突状细胞免疫启动功能的关键决定因素，并有助于解决过敏原诱导的气道炎症。

Mucosal Immunol. 2022 Feb;15(2):301-313. doi: 10.1038/s41385-021-00462-y. Epub 2021 Oct 20.

Myeloid-Derived Suppressor Cells Dampen Airway Inflammation Through Prostaglandin E2 Receptor 4.髓源性抑制细胞通过前列腺素 E2 受体 4 抑制气道炎症。

Front Immunol. 2021 Jul 12;12:695933. doi: 10.3389/fimmu.2021.695933. eCollection 2021.

Hypoxia drives murine neutrophil protein scavenging to maintain central carbon metabolism.缺氧驱动小鼠中性粒细胞蛋白吞噬作用以维持中心碳代谢。

J Clin Invest. 2021 May 17;131(10). doi: 10.1172/JCI134073.

Allergy. 2021 Nov;76(11):3314-3331. doi: 10.1111/all.14843. Epub 2021 May 6.

Metabolic Reprogramming Induces Germinal Center B Cell Differentiation through Bcl6 Locus Remodeling.代谢重编程通过 Bcl6 基因座重塑诱导生发中心 B 细胞分化。

Cell Rep. 2020 Nov 3;33(5):108333. doi: 10.1016/j.celrep.2020.108333.

Thioredoxin Peroxidase 2 Regulates Protective Th2 Immune Response in Mice by Directly Inducing Alternatively Activated Macrophages.硫氧还蛋白过氧化物酶2通过直接诱导替代性活化巨噬细胞来调节小鼠的保护性Th2免疫反应。

Front Immunol. 2020 Sep 25;11:2015. doi: 10.3389/fimmu.2020.02015. eCollection 2020.

CX3CR1 Deficiency Attenuates DNFB-Induced Contact Hypersensitivity Through Skewed Polarization Towards M2 Phenotype in Macrophages.CX3CR1 缺陷通过巨噬细胞向 M2 表型的倾斜极化来减轻 DNFB 诱导的接触超敏反应。

Int J Mol Sci. 2020 Oct 7;21(19):7401. doi: 10.3390/ijms21197401.

Metabolic Optimisation of Regulatory T Cells in Transplantation.移植中的调节性 T 细胞代谢优化。

Front Immunol. 2020 Sep 2;11:2005. doi: 10.3389/fimmu.2020.02005. eCollection 2020.

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验