Olmo Isabella G, Ferreira-Vieira Talita H, Ribeiro Fabiola M
Department of Biochemistry and Immunology, Instituto de Ciencias Biologicas, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.
Department of Biochemistry and Immunology, Instituto de Ciencias Biologicas, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil
Mol Pharmacol. 2016 Nov;90(5):609-619. doi: 10.1124/mol.116.104372. Epub 2016 Jun 23.
The metabotropic glutamate 5 receptor and the cannabinoid type 1 receptor are G protein-coupled receptors that are widely expressed in the central nervous system. Metabotropic glutamate 5 receptors, present at the postsynaptic site, are coupled to Gα proteins and display an excitatory response upon activation, whereas the cannabinoid type 1 receptor, mainly present at presynaptic terminals, is coupled to the G protein and triggers an inhibitory response. Recent studies suggest that the glutamatergic and endocannabinoid systems exhibit a functional interaction to modulate several neural processes. In this review, we discuss possible mechanisms involved in this crosstalk and its relationship with physiologic and pathologic conditions, including nociception, addiction, and fragile X syndrome.
代谢型谷氨酸5受体和大麻素1型受体是G蛋白偶联受体，在中枢神经系统中广泛表达。代谢型谷氨酸5受体存在于突触后位点，与Gα蛋白偶联，激活后表现出兴奋性反应，而大麻素1型受体主要存在于突触前终末，与G蛋白偶联并触发抑制性反应。最近的研究表明，谷氨酸能系统和内源性大麻素系统表现出功能相互作用，以调节多种神经过程。在本综述中，我们讨论了这种相互作用所涉及的可能机制及其与生理和病理状况的关系，包括伤害感受、成瘾和脆性X综合征。
