手性 N-杂环卡宾配体的刚性骨架合成及其在手性钯催化酰胺的分子内 α-芳基化反应中的应用。
Synthesis of chiral N-heterocyclic carbene ligands with rigid backbones and application to the palladium-catalyzed enantioselective intramolecular α-arylation of amides.
机构信息
Department of Synthetic Chemistry and Biological Chemistry, Kyoto University, Katsura, Kyoto 615-8510, Japan.
出版信息
Org Lett. 2011 Apr 1;13(7):1666-9. doi: 10.1021/ol200149s. Epub 2011 Mar 8.
PMID:21384887
Abstract
Chiral N-heterocyclic carbene (NHC) ligands having a 2,2'-bisquinoline-based C(2) symmetric skeleton were developed. The ligands exhibited good enantioselectivity in palladium-catalyzed intramolecular α-arylation of amides to give 3,3-disubsituted oxindoles.
摘要
手性 N-杂环卡宾（NHC）配体具有 2,2'-联喹啉为基础的 C(2)对称骨架。这些配体在钯催化的酰胺的分子内 α-芳基化反应中表现出良好的对映选择性，得到 3,3-二取代的氧化吲哚。
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