Bedford Robin B, Brenner Peter B, Elorriaga David, Harvey Jeremy N, Nunn Joshua
School of Chemistry, University of Bristol, Cantock's Close, Bristol, BS8 1TS, UK.
Quantum Chemistry and Physical Chemistry Section, Department of Chemistry, University of Leuven (KU Leuven), Celestijnenlaan 200F - box 2404, Leuven, Belgium.
Dalton Trans. 2016 Oct 12;45(40):15811-15817. doi: 10.1039/c6dt01823h.
The application of a variety of iron complexes with chelating amine ligands as pre-catalysts in the representative cross-coupling of 4-tolylmagnesium bromide with cyclohexyl bromide was investigated. The results from this study indicate the performance of the pre-catalyst is inversely proportional to the strength of the chelate or macrocyclic effect of the amine ligand, as determined by the propensity of the ligand to be displaced from the iron centre by reaction with excess benzyl magnesium chloride. The findings from this study are consistent with a catalytic cycle wherein the chelating amine ligand is not coordinated to the iron centre during turnover.
研究了多种带有螯合胺配体的铁配合物作为预催化剂在4-甲苯基溴化镁与环己基溴的典型交叉偶联反应中的应用。该研究结果表明，预催化剂的性能与胺配体的螯合或大环效应强度成反比，这是通过配体与过量苄基氯化镁反应而从铁中心被取代的倾向来确定的。该研究结果与一个催化循环一致，即在催化过程中螯合胺配体不与铁中心配位。
