Department of Chemistry, University of Rochester, Rochester, New York 14627, United States.
Org Lett. 2021 Aug 6;23(15):5958-5963. doi: 10.1021/acs.orglett.1c02053. Epub 2021 Jul 26.
Dilithium amides have been developed as a bespoke and general ligand for iron-catalyzed Kumada-Tamao-Corriu cross-coupling reactions, their design taking inspiration from previous mechanistic and structural studies. They allow for the cross-coupling of alkyl Grignard reagents with sp-hybridized electrophiles as well as aryl Grignard reagents with sp-hybridized electrophiles. This represents a rare example of a single iron-catalyzed system effective across diverse coupling reactions without significant modification of the catalytic protocol, as well as remaining operationally simple.
二锂酰胺已被开发为一种定制的、通用的配体，用于铁催化的 Kumada-Tamao-Corriu 交叉偶联反应，其设计灵感来自之前的机理和结构研究。它们允许烷基格氏试剂与 sp 杂化亲电试剂以及芳基格氏试剂与 sp 杂化亲电试剂进行交叉偶联。这代表了一个罕见的例子，即在不显著改变催化方案的情况下，单一铁催化体系在不同的偶联反应中有效，并且操作仍然简单。
