Wali Shradha, Sahoo Anupama, Puri Sushant, Alekseev Andrei, Nurieva Roza
Department of Immunology, M. D. Anderson Cancer Center, Houston, TX 77030, USA; The University of Texas Graduate School of Biomedical Sciences at Houston, TX, USA.
Sanford Burnham Prebys Medical Discovery Institute, Orlando, FL, USA.
Cytokine. 2016 Nov;87:9-19. doi: 10.1016/j.cyto.2016.06.010. Epub 2016 Jun 20.
T follicular helper (Tfh) cells are specialized subset of T helper (Th) cells necessary for germinal center reaction, affinity maturation and the differentiation of germinal center B cells to antibody-producing plasma B cells and memory B cells. The differentiation of Tfh cells is a multistage, multifactorial process involving a variety of cytokines, surface molecules and transcription factors. While Tfh cells are critical components of protective immune responses against pathogens, regulation of these cells is crucial to prevent autoimmunity and airway inflammation. Recently, it has been noted that Tfh cells could be potentially implicated either in cancer progression or prevention. Thus, the elucidation of the mechanisms that regulate Tfh cell differentiation, function and fate should highlight potential targets for novel therapeutic approaches. In this review, we summarize the latest advances in our understanding of the regulation of Tfh cell differentiation and their role in health and disease.
滤泡辅助性T（Tfh）细胞是辅助性T（Th）细胞的一个特殊亚群，对于生发中心反应、亲和力成熟以及生发中心B细胞分化为产生抗体的浆B细胞和记忆B细胞至关重要。Tfh细胞的分化是一个多阶段、多因素的过程，涉及多种细胞因子、表面分子和转录因子。虽然Tfh细胞是针对病原体的保护性免疫反应的关键组成部分，但对这些细胞的调节对于预防自身免疫和气道炎症至关重要。最近，有人指出Tfh细胞可能与癌症进展或预防有关。因此，阐明调节Tfh细胞分化、功能和命运的机制应能突出新型治疗方法的潜在靶点。在本综述中，我们总结了我们对Tfh细胞分化调节及其在健康和疾病中的作用的最新认识进展。
