Zhu Zhiming, Xiong Shiqiang, Li Qiang
Center for Hypertension and Metabolic Diseases, Department of Hypertension and Endocrinology, Daping Hospital, Third Military Medical University, Chongqing Institute of Hypertension, Chongqing, 400042, China.
Exp Physiol. 2016 Nov 1;101(11):1338-1344. doi: 10.1113/EP085568. Epub 2016 Aug 2.
What is the topic of this review? Transient receptor potential (TRP) channels are highly implicated in the pathogenesis of hypertension and the regulation of metabolism. What advances does it highlight? Dysfunction of TRP channels leads to hypertension and metabolic disorders. Elucidating the role of TRP channels in hypertension and metabolic vascular damage would facilitate the design of novel target therapeutics for these intractable diseases. Intracellular Ca homeostasis is critical for vascular function and the regulation of metabolism. Metabolic disorders are major risk factors for hypertension. A family of transient receptor potential (TRP) channels plays an important role in the regulation of cellular calcium signalling and cardiometabolic function. Emerging evidence indicates that TRP channels are highly implicated in the pathogenesis of hypertension and metabolic disorders. Dysfunction of TRP channels leads to hypertension and metabolic dysfunction. Activation of certain subtypes of TRP channels could attenuate metabolic vascular damage and alleviate hypertension. Therefore, elucidating the role of TRP channels in the physiological state and in cardiometabolic diseases will facilitate the design of novel targeted therapeutics for these intractable diseases.
本综述的主题是什么？瞬时受体电位（TRP）通道与高血压的发病机制及代谢调节密切相关。它突出了哪些进展？TRP通道功能障碍会导致高血压和代谢紊乱。阐明TRP通道在高血压和代谢性血管损伤中的作用将有助于设计针对这些难治性疾病的新型靶向疗法。细胞内钙稳态对血管功能和代谢调节至关重要。代谢紊乱是高血压的主要危险因素。瞬时受体电位（TRP）通道家族在细胞钙信号传导和心脏代谢功能调节中起重要作用。新出现的证据表明，TRP通道与高血压和代谢紊乱的发病机制高度相关。TRP通道功能障碍会导致高血压和代谢功能障碍。激活某些亚型的TRP通道可减轻代谢性血管损伤并缓解高血压。因此，阐明TRP通道在生理状态和心脏代谢疾病中的作用将有助于设计针对这些难治性疾病的新型靶向疗法。
