Department of Cardiovascular Surgery, Xijing Hospital, Fourth Military Medical University, Xi'an, 710032, China.
Department of Anesthesiology, Xi'an Children Hospital, Xi'an, 710003, China.
Curr Drug Targets. 2017;18(15):1733-1745. doi: 10.2174/1389450116666151019102052.
Cardiovascular disease is still the most frequent cause of death in both developed and developing countries while metabolic syndrome and myocardial ischemia reperfusion (I/R) injury are the common risk factors responsible for the impaired cardiac function. Transient receptor potential (TRP) channels are non-selective cation channels, that sense a broad range of stimuli from physical conditions such as stretch, to chemicals including capsaicin.
The diverse studies have revealed multifunctional roles of TRP channels in the physiological conditions and various diseases while some members of TRP channel superfamily are demonstrated to participate in the pathophysiology of cardiometabolic diseases and myocardial ischemia reperfusion injury. Here we discuss the roles of TRP channels in myocardial ischemia reperfusion and cardiometabolic diseases and their potential use in treating these diseases.
Regulation of TRP channels facilitates the control of metabolic syndrome such as obesity, diabetes mellitus, hypertension, and atherosclerosis. This review presents an overview of our current knowledge regarding the physiological functions of TRP channels in the metabolic and cardiovascular systems and their contributions to cardiometabolic diseases and I/R injury.
On the basis of these discoveries, the therapeutic potential of targeting novel TRP channels can be proposed for the treatment of cardiometabolic diseases and I/R injury.
心血管疾病仍然是发达国家和发展中国家最常见的死亡原因，而代谢综合征和心肌缺血再灌注（I/R）损伤是导致心脏功能受损的常见危险因素。瞬时受体电位（TRP）通道是非选择性阳离子通道，可感知从拉伸等物理条件到包括辣椒素在内的各种化学物质的广泛刺激。
多项研究揭示了 TRP 通道在生理条件和各种疾病中的多功能作用，而 TRP 通道超家族的一些成员被证明参与了心脏代谢疾病和心肌缺血再灌注损伤的病理生理学过程。在这里，我们讨论了 TRP 通道在心肌缺血再灌注和心脏代谢疾病中的作用及其在治疗这些疾病中的潜在用途。
TRP 通道的调节有助于控制代谢综合征，如肥胖、糖尿病、高血压和动脉粥样硬化。本综述概述了我们目前对 TRP 通道在代谢和心血管系统中的生理功能及其对心脏代谢疾病和 I/R 损伤的贡献的了解。
基于这些发现，可以提出针对新型 TRP 通道的治疗潜力，用于治疗心脏代谢疾病和 I/R 损伤。
