Chen Hong-Jhang, Lin Yii-Jeng, Wu Pei-Chen, Hsu Wei-Hsiang, Hu Wan-Chung, Wu Trong-Neng, Chen Fang-Pey, Lin Yun-Lian
National Research Institute of Chinese Medicine, Taipei 112, Taiwan.
Taipei Veterans General Hospital, Center for Traditional Medicine, Taipei 112, Taiwan.
Evid Based Complement Alternat Med. 2016;2016:9437382. doi: 10.1155/2016/9437382. Epub 2016 May 31.
Traditional Chinese medicine (TCM) formulates treatment according to body constitution (BC) differentiation. Different constitutions have specific metabolic characteristics and different susceptibility to certain diseases. This study aimed to assess the Yang-Xu constitution using a body constitution questionnaire (BCQ) and clinical blood variables. A BCQ was employed to assess the clinical manifestation of Yang-Xu. The logistic regression model was conducted to explore the relationship between BC scores and biomarkers. Leave-one-out cross-validation (LOOCV) and K-fold cross-validation were performed to evaluate the accuracy of a predictive model in practice. Decision trees (DTs) were conducted to determine the possible relationships between blood biomarkers and BC scores. According to the BCQ analysis, 49% participants without any BC were classified as healthy subjects. Among them, 130 samples were selected for further analysis and divided into two groups. One group comprised healthy subjects without any BC (68%), while subjects of the other group, named as the sub-healthy group, had three BCs (32%). Six biomarkers, CRE, TSH, HB, MONO, RBC, and LH, were found to have the greatest impact on BCQ outcomes in Yang-Xu subjects. This study indicated significant biochemical differences in Yang-Xu subjects, which may provide a connection between blood variables and the Yang-Xu BC.
中医根据体质辨证制定治疗方案。不同体质具有特定的代谢特征，对某些疾病的易感性也不同。本研究旨在使用体质问卷（BCQ）和临床血液变量评估阳虚体质。采用BCQ评估阳虚的临床表现。进行逻辑回归模型以探索BC评分与生物标志物之间的关系。采用留一法交叉验证（LOOCV）和K折交叉验证来评估预测模型在实际应用中的准确性。构建决策树（DTs）以确定血液生物标志物与BC评分之间的可能关系。根据BCQ分析，49%无任何体质类型的参与者被归类为健康受试者。其中，选取130个样本进行进一步分析并分为两组。一组为无任何体质类型的健康受试者（68%），另一组为亚健康组，有三种体质类型（32%）。发现六种生物标志物，即肌酐（CRE）、促甲状腺激素（TSH）、血红蛋白（HB）、单核细胞（MONO）、红细胞（RBC）和促黄体生成素（LH），对阳虚受试者的BCQ结果影响最大。本研究表明阳虚受试者存在显著的生化差异，这可能为血液变量与阳虚体质之间建立联系。
