光延反应的非常规应用：选择性黄酮木脂素脱水生成扁蒴藤素。

Unconventional application of the Mitsunobu reaction: Selective flavonolignan dehydration yielding hydnocarpins.

作者信息

Huang Guozheng, Schramm Simon, Heilmann Jörg, Biedermann David, Křen Vladimír, Decker Michael

机构信息

Pharmazeutische und Medizinische Chemie, Institut für Pharmazie und Lebensmittelchemie, Julius-Maximilians-Universität Würzburg, Am Hubland, D-97074 Würzburg, Germany; College of Life and Environmental Sciences, Shanghai Normal University, Shanghai, P. R. China.

Pharmazeutische und Medizinische Chemie, Institut für Pharmazie und Lebensmittelchemie, Julius-Maximilians-Universität Würzburg, Am Hubland, D-97074 Würzburg, Germany.

出版信息

Beilstein J Org Chem. 2016 Apr 8;12:662-9. doi: 10.3762/bjoc.12.66. eCollection 2016.

Various Mitsunobu conditions were investigated for a series of flavonolignans (silybin A, silybin B, isosilybin A, and silychristin A) to achieve either selective esterification in position C-23 or dehydration in a one-pot reaction yielding the biologically important enantiomers of hydnocarpin D, hydnocarpin and isohydnocarpin, respectively. This represents the only one-pot semi-synthetic method to access these flavonolignans in high yields.