Institute of Microbiology AS CR, Centre of Biocatalysis and Biotransformation, Vídeňská 1083, Prague 4, CZ 14220, Czech Republic.
Nat Prod Rep. 2014 Sep;31(9):1138-57. doi: 10.1039/c3np70122k.
Silybin, a secondary metabolite isolated from the seeds of the blessed milk thistle (Silybum marianum) was discovered as the first member of a new family of natural compounds called flavonolignans in 1959. Over the years it has received the research attention of many organic chemists. This research has resulted in a number of semisynthetic derivatives prepared in an effort to modulate and better target the biological activities of silybin or to improve its physical properties, such as its solubility. A fundamental breakthrough in silybin chemistry was the determination of the absolute configurations of silybin A and silybin B, and the development of methods for their separation. This review covers articles dealing with silybin chemistry and also summarizes all the derivatives prepared.
水飞蓟宾，一种从奶蓟草（水飞蓟）种子中分离出来的次生代谢产物，于 1959 年被发现，是一类新型天然化合物——类黄酮木脂素的第一个成员。多年来，它受到了许多有机化学家的研究关注。这些研究产生了许多半合成衍生物，旨在调节和更好地针对水飞蓟宾的生物活性，或改善其物理性质，如溶解度。水飞蓟宾化学的一个重大突破是确定了水飞蓟宾 A 和水飞蓟宾 B 的绝对构型，并开发了它们的分离方法。本综述涵盖了有关水飞蓟宾化学的文章，并对所有制备的衍生物进行了总结。
