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通过铃木-宫浦交叉偶联反应合成对称和不对称取代的3,5-二芳基-2,4,6-三甲基吡啶的便捷方法。

A convenient route to symmetrically and unsymmetrically substituted 3,5-diaryl-2,4,6-trimethylpyridines via Suzuki-Miyaura cross-coupling reaction.

作者信息

Błachut Dariusz, Szawkało Joanna, Czarnocki Zbigniew

机构信息

Forensic Laboratory, Internal Security Agency, 1 Sierpnia 30A, 02-134 Warsaw, Poland, Tel.: +48 693830760.

Faculty of Chemistry, University of Warsaw, Pasteura 1, 02-093 Warsaw, Poland.

出版信息

Beilstein J Org Chem. 2016 Apr 28;12:835-45. doi: 10.3762/bjoc.12.82. eCollection 2016.

DOI:10.3762/bjoc.12.82
PMID:27340474
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4901938/
Abstract

A series of differently substituted 3,5-diaryl-2,4,6-trimethylpyridines were prepared and characterized using the Suzuki-Miyaura coupling reaction with accordingly selected bromo-derivatives and arylboronic acids. The reaction conditions were carefully optimized allowing high yield of isolated products and also the construction of unsymmetrically substituted diarylpyridines, difficult to access by other methods.

摘要

通过与相应选择的溴代衍生物和芳基硼酸进行铃木-宫浦偶联反应，制备并表征了一系列不同取代的3,5-二芳基-2,4,6-三甲基吡啶。反应条件经过精心优化，使得分离产物的产率较高，并且能够构建不对称取代的二芳基吡啶，而这是其他方法难以实现的。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6160/4901938/6bcc91e0bc10/Beilstein_J_Org_Chem-12-835-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6160/4901938/c7d245ff446b/Beilstein_J_Org_Chem-12-835-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6160/4901938/286349814fb0/Beilstein_J_Org_Chem-12-835-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6160/4901938/af21029bd06b/Beilstein_J_Org_Chem-12-835-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6160/4901938/efce66eb2719/Beilstein_J_Org_Chem-12-835-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6160/4901938/6bcc91e0bc10/Beilstein_J_Org_Chem-12-835-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6160/4901938/c7d245ff446b/Beilstein_J_Org_Chem-12-835-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6160/4901938/286349814fb0/Beilstein_J_Org_Chem-12-835-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6160/4901938/af21029bd06b/Beilstein_J_Org_Chem-12-835-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6160/4901938/efce66eb2719/Beilstein_J_Org_Chem-12-835-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6160/4901938/6bcc91e0bc10/Beilstein_J_Org_Chem-12-835-g006.jpg

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