通过铃木-宫浦交叉偶联反应合成对称和不对称取代的3,5-二芳基-2,4,6-三甲基吡啶的便捷方法。

A convenient route to symmetrically and unsymmetrically substituted 3,5-diaryl-2,4,6-trimethylpyridines via Suzuki-Miyaura cross-coupling reaction.

作者信息

Błachut Dariusz, Szawkało Joanna, Czarnocki Zbigniew

机构信息

Forensic Laboratory, Internal Security Agency, 1 Sierpnia 30A, 02-134 Warsaw, Poland, Tel.: +48 693830760.

Faculty of Chemistry, University of Warsaw, Pasteura 1, 02-093 Warsaw, Poland.

出版信息

Beilstein J Org Chem. 2016 Apr 28;12:835-45. doi: 10.3762/bjoc.12.82. eCollection 2016.

A series of differently substituted 3,5-diaryl-2,4,6-trimethylpyridines were prepared and characterized using the Suzuki-Miyaura coupling reaction with accordingly selected bromo-derivatives and arylboronic acids. The reaction conditions were carefully optimized allowing high yield of isolated products and also the construction of unsymmetrically substituted diarylpyridines, difficult to access by other methods.