Slivka Iu I, Klimniuk E V, Tabachuk O E
Probl Tuberk. 1989(4):39-42.
Experiments on rats showed that 14-day exposure of the animals to pyrazinamide in a dose of 1.5 g/kg induced marked disorders in cholopoiesis and lowering of the reduced glutathion levels in the liver. When pyrazinamide was used in combination with isoniazid or rifampicin a marked increase in the activity of aspartate and alanine aminotransferases in blood serum and induction of lipid peroxidation in the liver were observed in addition to the disorders in cholopoiesis and lowering of the reduced glutathion levels. Combined use of pyraxinamide, isoniazid and rifampicin induced disorders in the liver state not differing significantly from those observed with using pyrazinamide in combination with isoniazid or rifampicin.
对大鼠的实验表明，给动物以1.5克/千克的剂量连续14天服用吡嗪酰胺，会导致明显的胆细胞生成紊乱以及肝脏中还原型谷胱甘肽水平降低。当吡嗪酰胺与异烟肼或利福平联合使用时，除了胆细胞生成紊乱和还原型谷胱甘肽水平降低外，还观察到血清中天冬氨酸和丙氨酸转氨酶活性显著增加以及肝脏中脂质过氧化的诱导。吡嗪酰胺、异烟肼和利福平联合使用导致的肝脏状态紊乱与吡嗪酰胺与异烟肼或利福平联合使用时观察到的紊乱无显著差异。
