al Sarraf K A, Michielsen P P, Hauben E I, Lefebure A, Ramon A M, Van Marck E A, Pelckmans P A
Division of Gastroenterology, University of Antwerp (U.I.A.), Belgium.
Acta Gastroenterol Belg. 1996 Oct-Dec;59(4):251-3.
We report on a patient who developed extensive centrolobular liver necrosis after a treatment with low-dose (25 mg/kg/d) pyrazinamide for only 4 weeks, combined with rifampicin, 600 mg/d). In the past, the patient already developed severe aminotransferase elevations under isoniazid treatment. After prompt withdrawal of the drugs, a gradual decline of the aminotransferases was observed. No signs of hepatic failure developed. Pyrazinamide has to be used with caution, even in low-dose, especially when combined with rifampicin.
我们报告了一名患者，该患者在仅接受4周低剂量（25毫克/千克/天）吡嗪酰胺治疗（联合每日600毫克利福平）后出现广泛的肝小叶中心坏死。过去，该患者在接受异烟肼治疗时已出现严重的转氨酶升高。在迅速停药后，观察到转氨酶逐渐下降。未出现肝衰竭迹象。即使是低剂量，吡嗪酰胺也必须谨慎使用，尤其是与利福平合用时。
