Tasduq S A, Singh K, Satti N K, Gupta D K, Suri K A, Johri R K
Division of Pharmacology and Natural Products Chemistry, Regional Research Laboratory, (CSIR), Canal Road, Jammu - Tawi 180 001, India.
Hum Exp Toxicol. 2006 Mar;25(3):111-8. doi: 10.1191/0960327106ht601oa.
Terminalia chebula Gertn. (Combetraceae) is an important herbal drug in Ayurvedic pharmacopea. In the present study, a 95% ethanolic extract of T. chebula (fruit) (TC extract), which was chemically characterized on the basis of chebuloside II as a marker, was investigated for hepatoprotective activity against anti-tuberculosis (anti-TB) drug-induced toxicity. TC extract was found to prevent the hepatotoxicity caused by the administration of rifampicin (RIF), isoniazid (INH) and pyrazinamide (PZA) (in combination) in a sub-chronic mode (12 weeks). The hepatoprotective effect of TC extract could be attributed to its prominent anti-oxidative and membrane stabilizing activities. The changes in biochemical observations were supported by histological profile.
诃子（使君子科）是阿育吠陀药典中的一种重要草药。在本研究中，以诃子苷II为标志物进行化学表征的诃子（果实）95%乙醇提取物（TC提取物），被研究了对抗结核药物诱导毒性的肝保护活性。发现TC提取物可预防以亚慢性方式（12周）给予利福平（RIF）、异烟肼（INH）和吡嗪酰胺（PZA）（联合使用）所引起的肝毒性。TC提取物的肝保护作用可归因于其显著的抗氧化和膜稳定活性。生化观察结果的变化得到了组织学特征的支持。
