Nabouli M R, Lassoued L, Bakri Z, Moghannem M
College of Medicine, King Faisal University Saudi Arabia.
Maternity and Alhasa, Saudi Arabia.
Diabetes Metab Syndr. 2016 Oct-Dec;10(4):183-185. doi: 10.1016/j.dsx.2016.06.001. Epub 2016 Jun 8.
The aim of our study is to measure total Magnesium in pregnant women screened for GDM and to compare total magnesium between whom were diagnosed having GDM and those having normal pregnancy.
Our study is a prospective study involved 99 pregnant women referred to Maternity and Child Hospital Al Ahsa (Kingdom of Saudi Arabia) for 100g Oral Glucose Tolerance test. All included pregnant women were in their 24-28 weeks of gestation with free past medical history and were free for any medicine. A 100-g Oral Glucose Tolerance (OGTT) with total plasma magnesium measurement were done to all included women. All patient were followed tell delivery.
Among 99 patients enrolled in our study, GDM was diagnosed in 19 patients (19.2%). Fifteen patients have normal fasting glycaemia and were diagnosed having GDM on 100-g OGTT. Four patients have fasting glycaemia more than 126mg/dl (7mmol/l) confirming the diagnosis of GDM. Hypomagnesemia was confirmed in eight patients (8.08%). no one of them had GDM. The serum magnesium concentration in GDM women was lower that of normal pregnant women but the difference was not significant. (0.89±0.1 vs 0.92±0.2mmol/l, p=0.51). BMI, systolic and diastolic blood pressure were not significantly different between the pregnant women who developed or not gestational diabetes.
In our study, the development of GDM cannot be explained by low total serum magnesium. The low total serum magnesium in patient diagnosed having GDM compared to whom free of GDM and the importance of magnesium in the genesis of insulin resistance should encourage more large trial to explain the exact role of magnesium in the pathophysiology of GDM.
我们研究的目的是测量接受妊娠期糖尿病（GDM）筛查的孕妇体内的总镁含量，并比较确诊患有GDM的孕妇与正常妊娠孕妇的总镁含量。
我们的研究是一项前瞻性研究，涉及99名转诊至沙特阿拉伯王国阿赫萨妇幼医院进行100克口服葡萄糖耐量试验的孕妇。所有纳入的孕妇均处于妊娠24 - 28周，既往无病史且未服用任何药物。对所有纳入的妇女进行了100克口服葡萄糖耐量试验（OGTT）并测量血浆总镁含量。所有患者随访至分娩。
在我们研究纳入的99名患者中，19名患者（19.2%）被诊断为GDM。15名患者空腹血糖正常，但在100克OGTT检查中被诊断为GDM。4名患者空腹血糖高于126mg/dl（7mmol/l），确诊为GDM。8名患者（8.08%）被确诊为低镁血症。她们中没有人患有GDM。GDM女性的血清镁浓度低于正常妊娠女性，但差异不显著。（0.89±0.1 vs 0.92±0.2mmol/l，p = 0.51）。发生或未发生妊娠期糖尿病的孕妇之间的体重指数、收缩压和舒张压无显著差异。
在我们的研究中，GDM的发生不能用血清总镁含量低来解释。与未患GDM的患者相比，被诊断患有GDM的患者血清总镁含量低，以及镁在胰岛素抵抗发生中的重要性，应促使开展更多大型试验以阐明镁在GDM病理生理学中的确切作用。
