• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

补充镁对妊娠期糖尿病患者妊娠结局的影响：一项随机对照试验的荟萃分析。

Effect of magnesium supplementation on pregnancy outcome in gestational diabetes mellitus patients: A meta-analysis of randomized controlled trials.

作者信息

Qu Qiuchan, Rong Rong, Yu Jinhua

机构信息

Department of Reproductive Health, Maternal and Child Health Hospital Affiliated to Nantong University Nantong China.

出版信息

Food Sci Nutr. 2022 Sep 7;10(10):3193-3202. doi: 10.1002/fsn3.2561. eCollection 2022 Oct.

DOI:10.1002/fsn3.2561
PMID:36249983
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9548361/
Abstract

Conflicting evidence exists regarding the effectiveness of magnesium supplementation during pregnancy in gestational diabetes mellitus (GDM) patients. This meta-analysis examines the effect of magnesium on glycemic indices and metabolic status in GDM. We searched databases for randomized controlled trials (RCTs) conducted, and after applying inclusion and exclusion criteria, a total of four RCTs were considered eligible for the analysis. Outcome parameters included markers for glycemic control and metabolic status. A total of four RCTs with 198 participants (control = 99; magnesium supplemented = 99) were selected for the analysis. Magnesium supplementation resulted in a significant reduction in markers of glycemic control-fasting plasma glucose (standard mean difference ( ) = -0.83; 95% CI: [-1.13, -0.54]; -value <.0001), and insulin levels (  = -0.95; 95% CI: [-1.38, -0.52]; -value <.0001). Also, Mg intake resulted in altered oxidative stress markers TAC (  = 1.09; 95% CI: [0.10, 2.07]; -value = .03) of the pregnant women. No significant effect on GSH and CRP levels was observed. This study provides evidence of the positive effects of magnesium intervention on insulin sensitivity and oxidative stress in GDM patients.

摘要

关于妊娠期糖尿病（GDM）患者孕期补充镁的有效性，存在相互矛盾的证据。本荟萃分析研究了镁对GDM患者血糖指数和代谢状态的影响。我们检索了已开展的随机对照试验（RCT）数据库，在应用纳入和排除标准后，共有四项RCT被认为符合分析条件。结局参数包括血糖控制和代谢状态的标志物。总共选择了四项RCT，共198名参与者（对照组 = 99名；补充镁组 = 99名）进行分析。补充镁导致血糖控制标志物——空腹血糖（标准均差（SMD）= -0.83；95%置信区间：[-1.13, -0.54]；P值 <.0001）和胰岛素水平（SMD = -0.95；95%置信区间：[-1.38, -0.52]；P值 <.0001）显著降低。此外，镁的摄入导致孕妇氧化应激标志物总抗氧化能力（TAC）发生变化（SMD = 1.09；95%置信区间：[0.10, 2.07]；P值 = .03）。未观察到对谷胱甘肽（GSH）和C反应蛋白（CRP）水平有显著影响。本研究提供了镁干预对GDM患者胰岛素敏感性和氧化应激有积极作用的证据。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f646/9548361/60429b2a8d89/FSN3-10-3193-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f646/9548361/d272b39ac0ac/FSN3-10-3193-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f646/9548361/e5c22bc973a1/FSN3-10-3193-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f646/9548361/97997770b3ab/FSN3-10-3193-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f646/9548361/0263ad8ba310/FSN3-10-3193-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f646/9548361/fd9d34db517e/FSN3-10-3193-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f646/9548361/60429b2a8d89/FSN3-10-3193-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f646/9548361/d272b39ac0ac/FSN3-10-3193-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f646/9548361/e5c22bc973a1/FSN3-10-3193-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f646/9548361/97997770b3ab/FSN3-10-3193-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f646/9548361/0263ad8ba310/FSN3-10-3193-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f646/9548361/fd9d34db517e/FSN3-10-3193-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f646/9548361/60429b2a8d89/FSN3-10-3193-g007.jpg

相似文献

1
Effect of magnesium supplementation on pregnancy outcome in gestational diabetes mellitus patients: A meta-analysis of randomized controlled trials.补充镁对妊娠期糖尿病患者妊娠结局的影响：一项随机对照试验的荟萃分析。
Food Sci Nutr. 2022 Sep 7;10(10):3193-3202. doi: 10.1002/fsn3.2561. eCollection 2022 Oct.
2
Folic acid supplementation and malaria susceptibility and severity among people taking antifolate antimalarial drugs in endemic areas.在流行地区，服用抗叶酸抗疟药物的人群中，叶酸补充剂与疟疾易感性和严重程度的关系。
Cochrane Database Syst Rev. 2022 Feb 1;2(2022):CD014217. doi: 10.1002/14651858.CD014217.
3
Magnesium supplementation for glycemic status in women with gestational diabetes: a systematic review and meta-analysis.镁补充剂对妊娠期糖尿病妇女血糖状况的影响：系统评价和荟萃分析。
Gynecol Endocrinol. 2022 Mar;38(3):202-206. doi: 10.1080/09513590.2021.1988558. Epub 2021 Dec 15.
4
Magnesium-zinc-calcium-vitamin D co-supplementation improves glycemic control and markers of cardiometabolic risk in gestational diabetes: a randomized, double-blind, placebo-controlled trial.镁锌钙维生素 D 联合补充改善妊娠期糖尿病患者的血糖控制和心血管代谢风险标志物：一项随机、双盲、安慰剂对照试验。
Appl Physiol Nutr Metab. 2018 Jun;43(6):565-570. doi: 10.1139/apnm-2017-0521. Epub 2018 Jan 9.
5
Retracted: Magnesium supplementation affects metabolic status and pregnancy outcomes in gestational diabetes: a randomized, double-blind, placebo-controlled trial.撤稿：补充镁对妊娠期糖尿病患者代谢状况及妊娠结局的影响：一项随机、双盲、安慰剂对照试验。
Am J Clin Nutr. 2015 Jul;102(1):222-9. doi: 10.3945/ajcn.114.098616. Epub 2015 May 27.
6
Effects of Probiotic Supplement in Pregnant Women with Gestational Diabetes Mellitus: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.益生菌补充剂对妊娠期糖尿病孕妇的影响：随机对照试验的系统评价和荟萃分析。
J Diabetes Res. 2019 Sep 5;2019:5364730. doi: 10.1155/2019/5364730. eCollection 2019.
7
The effects of vitamin and mineral supplementation on women with gestational diabetes mellitus.维生素和矿物质补充剂对妊娠期糖尿病妇女的影响。
BMC Endocr Disord. 2021 May 24;21(1):106. doi: 10.1186/s12902-021-00712-x.
8
The efficacy of magnesium supplementation for gestational diabetes: A meta-analysis of randomized controlled trials.镁补充剂治疗妊娠期糖尿病的疗效：一项随机对照试验的荟萃分析。
Eur J Obstet Gynecol Reprod Biol. 2024 Feb;293:84-90. doi: 10.1016/j.ejogrb.2023.12.014. Epub 2023 Dec 12.
9
Inositol supplementation for the prevention and treatment of gestational diabetes mellitus: a meta-analysis of randomized controlled trials.补充肌醇预防和治疗妊娠期糖尿病：一项随机对照试验的荟萃分析
Arch Gynecol Obstet. 2024 May;309(5):1959-1969. doi: 10.1007/s00404-023-07100-x. Epub 2023 Jun 12.
10
Antenatal dietary supplementation with myo-inositol in women during pregnancy for preventing gestational diabetes.孕期女性产前补充肌醇以预防妊娠期糖尿病。
Cochrane Database Syst Rev. 2015 Dec 17;2015(12):CD011507. doi: 10.1002/14651858.CD011507.pub2.

引用本文的文献

1
Association between oxidative balance score and gestational diabetes mellitus risk: a case-control study.氧化平衡评分与妊娠期糖尿病风险之间的关联：一项病例对照研究。
BMC Endocr Disord. 2025 Sep 4;25(1):205. doi: 10.1186/s12902-025-02028-6.
2
The efficacy of calcium and vitamin D3 supplementation in improving pregnancy and neonatal outcomes.补充钙和维生素D3对改善妊娠及新生儿结局的疗效。
Front Pediatr. 2025 Jun 12;13:1605489. doi: 10.3389/fped.2025.1605489. eCollection 2025.
3
A prospective study of early pregnancy metal concentrations and gestational diabetes mellitus based on a birth cohort in Northwest China.

本文引用的文献

1
Short- and long-term outcomes of gestational diabetes and its treatment on fetal development.妊娠期糖尿病及其治疗对胎儿发育的短期和长期结局。
Prenat Diagn. 2020 Aug;40(9):1085-1091. doi: 10.1002/pd.5768. Epub 2020 Jul 1.
2
Obstetrical Complications and Long-Term Cardiovascular Outcomes.产科并发症与长期心血管结局
Curr Hypertens Rep. 2020 Sep 17;22(11):92. doi: 10.1007/s11906-020-01102-9.
3
Investigating the Relationship between Magnesium levels and Diabetes Mellitus in Pregnant Women.探究孕妇镁水平与糖尿病之间的关系。
基于中国西北某出生队列的早期妊娠金属浓度与妊娠期糖尿病的前瞻性研究。
BMC Pregnancy Childbirth. 2025 Apr 2;25(1):387. doi: 10.1186/s12884-025-07336-2.
4
Combined exposure to multiple essential elements and cadmium at early pregnancy on gestational diabetes mellitus: a prospective cohort study.孕早期多种必需元素与镉联合暴露对妊娠期糖尿病的影响：一项前瞻性队列研究
Front Nutr. 2023 Dec 6;10:1278617. doi: 10.3389/fnut.2023.1278617. eCollection 2023.
5
A Narrative Review on Effects of Maternal Bariatric Surgery on Offspring.关于母体减肥手术对后代影响的叙述性综述
Cureus. 2023 Nov 8;15(11):e48513. doi: 10.7759/cureus.48513. eCollection 2023 Nov.
6
Nutritional and Exercise-Focused Lifestyle Interventions and Glycemic Control in Women with Diabetes in Pregnancy: A Systematic Review and Meta-Analysis of Randomized Clinical Trials.妊娠糖尿病女性的营养和运动为重点的生活方式干预与血糖控制：随机临床试验的系统评价和荟萃分析。
Nutrients. 2023 Jan 9;15(2):323. doi: 10.3390/nu15020323.
Int J Mol Cell Med. 2019 Summer;8(3):223-231. doi: 10.22088/IJMCM.BUMS.8.3.223.
4
Effects of Nutritional Strategies on Glucose Homeostasis in Gestational Diabetes Mellitus: A Systematic Review and Network Meta-Analysis.营养策略对妊娠期糖尿病患者血糖稳态的影响：系统评价和网络荟萃分析。
J Diabetes Res. 2020 Feb 23;2020:6062478. doi: 10.1155/2020/6062478. eCollection 2020.
5
Pregnancy outcomes according to the definition of gestational diabetes.根据妊娠期糖尿病的定义的妊娠结局。
PLoS One. 2020 Mar 5;15(3):e0229496. doi: 10.1371/journal.pone.0229496. eCollection 2020.
6
Serum magnesium and high-sensitivity C-reactive protein as a predictor for gestational diabetes mellitus in Sudanese pregnant women.血清镁和高敏 C 反应蛋白作为苏丹孕妇妊娠期糖尿病的预测指标。
BMC Pregnancy Childbirth. 2019 Aug 16;19(1):301. doi: 10.1186/s12884-019-2429-x.
7
Nutritional Supplementation for the Prevention and/or Treatment of Gestational Diabetes Mellitus.营养补充剂用于预防和/或治疗妊娠糖尿病。
Curr Diab Rep. 2019 Aug 1;19(9):73. doi: 10.1007/s11892-019-1199-1.
8
The prevalence and risk factors of gestational diabetes mellitus in Turkey: a systematic review and meta-analysis.土耳其妊娠糖尿病的患病率及危险因素：系统评价和荟萃分析。
J Matern Fetal Neonatal Med. 2021 Apr;34(8):1331-1341. doi: 10.1080/14767058.2019.1635109. Epub 2019 Jul 2.
9
The effects of magnesium-zinc-calcium-vitamin D co-supplementation on biomarkers of inflammation, oxidative stress and pregnancy outcomes in gestational diabetes.镁锌钙维生素 D 联合补充对妊娠期糖尿病炎症、氧化应激生物标志物及妊娠结局的影响。
BMC Pregnancy Childbirth. 2019 Mar 29;19(1):107. doi: 10.1186/s12884-019-2258-y.
10
Pre-pregnancy dietary micronutrient adequacy is associated with lower risk of developing gestational diabetes in Australian women.孕前饮食微量营养素充足与澳大利亚女性发生妊娠期糖尿病的风险降低相关。
Nutr Res. 2019 Feb;62:32-40. doi: 10.1016/j.nutres.2018.11.006. Epub 2018 Nov 13.