高通量生物学时代的疫苗学。
Vaccinology in the era of high-throughput biology.
作者信息
Nakaya Helder I, Pulendran Bali
机构信息
School of Pharmaceutical Sciences, University of São Paulo, São Paulo, Brazil Emory Vaccine Center and Yerkes National Primate Research Center, Atlanta, GA 30329, USA Department of Pathology, Emory University School of Medicine, Atlanta, Georgia 30322, USA.
Emory Vaccine Center and Yerkes National Primate Research Center, Atlanta, GA 30329, USA Department of Pathology, Emory University School of Medicine, Atlanta, Georgia 30322, USA
出版信息
Philos Trans R Soc Lond B Biol Sci. 2015 Jun 19;370(1671). doi: 10.1098/rstb.2014.0146.
Vaccination has been tremendously successful saving lives and preventing infections. However, the development of vaccines against global pandemics such as HIV, malaria and tuberculosis has been obstructed by several challenges. A major challenge is the lack of knowledge about the correlates and mechanisms of protective immunity. Recent advances in the application of systems biological approaches to analyse immune responses to vaccination in humans are beginning to yield new insights about mechanisms of vaccine immunity, and to define molecular signatures, induced rapidly after vaccination, that correlate with and predict vaccine induced immunity. Here, we review these advances and discuss the potential of this systems vaccinology approach in defining novel correlates of protection in clinical trials, and in infection-induced 'experimental challenge models' in humans.
疫苗接种在拯救生命和预防感染方面取得了巨大成功。然而，针对艾滋病病毒、疟疾和结核病等全球大流行疾病的疫苗研发面临着诸多挑战。一个主要挑战是缺乏对保护性免疫的相关因素和机制的了解。系统生物学方法在分析人类疫苗接种免疫反应中的应用取得的最新进展，开始为疫苗免疫机制带来新的见解，并确定接种疫苗后迅速诱导产生的、与疫苗诱导免疫相关并可预测其效果的分子特征。在此，我们综述这些进展，并讨论这种系统疫苗学方法在确定临床试验中新型保护相关因素以及人类感染诱导的“实验性激发模型”中的潜力。
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