肺腺癌急性缺血性卒中治疗期间的华法林抵抗性深静脉血栓形成
Warfarin-Resistant Deep Vein Thrombosis during the Treatment of Acute Ischemic Stroke in Lung Adenocarcinoma.
作者信息
Naito Hiroyuki, Aoki Shiro, Sumi Naoko, Ochi Kazuhide, Hosomi Naohisa, Maruyama Hirofumi, Matsumoto Masayasu
机构信息
Department of Clinical Neuroscience and Therapeutics, Hiroshima University Graduate School of Biomedical and Health Sciences, Hiroshima, Japan.
Department of Clinical Neuroscience and Therapeutics, Hiroshima University Graduate School of Biomedical and Health Sciences, Hiroshima, Japan.
出版信息
J Stroke Cerebrovasc Dis. 2016 Sep;25(9):e141-5. doi: 10.1016/j.jstrokecerebrovasdis.2016.04.026. Epub 2016 Jun 22.
CASE REPORT
A 66-year-old man with acute ischemic stroke in the setting of lung adenocarcinoma developed acute-onset deep vein thrombosis (DVT) of the lower limbs after changing to warfarin from a heparin combination. The diagnosis of warfarin-resistant DVT was established based on the laboratory data and clinical evaluation. Heparin administration resulted in good control of thrombin regulation. Cancer patients are at high risk of venous thromboembolism, and the combination of these 2 conditions is known as Trousseau's syndrome.
CONCLUSION
Our report suggests that heparin administration may provide good control of thromboembolic events, although there is no established medical treatment to extend the survival of patients with Trousseau's syndrome.
病例报告
一名66岁男性，患有肺腺癌并发生急性缺血性中风，在从肝素联合用药转换为华法林后，出现了急性下肢深静脉血栓形成（DVT）。基于实验室数据和临床评估，确诊为对华法林耐药的DVT。肝素治疗有效控制了凝血酶调节。癌症患者发生静脉血栓栓塞的风险很高，这两种情况同时出现被称为Trousseau综合征。
结论
我们的报告表明，尽管尚无确定的医疗方法可延长患有Trousseau综合征患者的生存期，但肝素治疗可能有效控制血栓栓塞事件。
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