Gnep Khémara, Fargeas Auréline, Gutiérrez-Carvajal Ricardo E, Commandeur Frédéric, Mathieu Romain, Ospina Juan D, Rolland Yan, Rohou Tanguy, Vincendeau Sébastien, Hatt Mathieu, Acosta Oscar, de Crevoisier Renaud
INSERM, U1099, Rennes, France.
Université de Rennes 1, LTSI, Rennes, France.
J Magn Reson Imaging. 2017 Jan;45(1):103-117. doi: 10.1002/jmri.25335. Epub 2016 Jun 27.
To explore the association between magnetic resonance imaging (MRI), including Haralick textural features, and biochemical recurrence following prostate cancer radiotherapy.
In all, 74 patients with peripheral zone localized prostate adenocarcinoma underwent pretreatment 3.0T MRI before external beam radiotherapy. Median follow-up of 47 months revealed 11 patients with biochemical recurrence. Prostate tumors were segmented on T -weighted sequences (T -w) and contours were propagated onto the coregistered apparent diffusion coefficient (ADC) images. We extracted 140 image features from normalized T -w and ADC images corresponding to first-order (n = 6), gradient-based (n = 4), and second-order Haralick textural features (n = 130). Four geometrical features (tumor diameter, perimeter, area, and volume) were also computed. Correlations between Gleason score and MRI features were assessed. Cox regression analysis and random survival forests (RSF) were performed to assess the association between MRI features and biochemical recurrence.
Three T -w and one ADC Haralick textural features were significantly correlated with Gleason score (P < 0.05). Twenty-eight T -w Haralick features and all four geometrical features were significantly associated with biochemical recurrence (P < 0.05). The most relevant features were Haralick features T -w contrast, T -w difference variance, ADC median, along with tumor volume and tumor area (C-index from 0.76 to 0.82; P < 0.05). By combining these most powerful features in an RSF model, the obtained C-index was 0.90.
T -w Haralick features appear to be strongly associated with biochemical recurrence following prostate cancer radiotherapy.
3 J. Magn. Reson. Imaging 2017;45:103-117.
探讨包括哈拉里克纹理特征在内的磁共振成像（MRI）与前列腺癌放疗后生化复发之间的关联。
共有74例外周带局限性前列腺腺癌患者在接受外照射放疗前接受了治疗前3.0T MRI检查。中位随访47个月发现11例患者出现生化复发。在T加权序列（T-w）上对前列腺肿瘤进行分割，并将轮廓投影到配准的表观扩散系数（ADC）图像上。我们从归一化的T-w和ADC图像中提取了140个图像特征，分别对应一阶特征（n = 6）、基于梯度的特征（n = 4）和二阶哈拉里克纹理特征（n = 130）。还计算了四个几何特征（肿瘤直径、周长、面积和体积）。评估了 Gleason评分与MRI特征之间的相关性。进行Cox回归分析和随机生存森林（RSF）分析，以评估MRI特征与生化复发之间的关联。
三个T-w和一个ADC哈拉里克纹理特征与Gleason评分显著相关（P < 0.05）。28个T-w哈拉里克特征和所有四个几何特征与生化复发显著相关（P < 0.05）。最相关的特征是哈拉里克特征T-w对比度、T-w差异方差、ADC中位数，以及肿瘤体积和肿瘤面积（C指数为0.76至0.82；P < 0.05）。通过在RSF模型中组合这些最强大的特征，获得的C指数为0.90。
T-w哈拉里克特征似乎与前列腺癌放疗后的生化复发密切相关。
3 J. Magn. Reson. Imaging 2017;45:103 - 117。
