Lobatto S, Daha M R, Westedt M L, Pauwels E K, Evers-Schouten J H, Voetman A A, Cats A, van Es L A
Department of Nephrology, University Hospital, Leiden, The Netherlands.
Scand J Rheumatol. 1989;18(2):89-96. doi: 10.3109/03009748909099923.
Investigation of the capacity of the mononuclear phagocyte system to remove immune complexes from the circulation was performed by the administration of 125I-labelled aggregates of human immunoglobulin G (AIgG) to patients with seropositive rheumatoid arthritis and healthy volunteers. It was found that the rate at which AIgG disappeared from the circulation was significantly prolonged in patients with RA, t1/2 61 +/- 49 min, versus 26 +/- 8 min in healthy volunteers (p less than 0.01). We were not able to establish a correlation between the t1/2 of AIgG and immune complex levels in the circulation, or between t1/2 and articular disease activity (Ritchie index). The sites of removal of AIgG from the circulation were analysed by determining radioactivity levels detectable over liver, spleen and heart. No correlation was found between t1/2 and liver/spleen uptake ratios. We have demonstrated that the removal of AIgG from the circulation of patients with RA is abnormal, though the biological significance of this finding remains to be determined.
通过给血清阳性类风湿性关节炎患者和健康志愿者注射125I标记的人免疫球蛋白G（AIgG）聚集体，对单核吞噬细胞系统从循环中清除免疫复合物的能力进行了研究。结果发现，RA患者体内AIgG从循环中消失的速率显著延长，半衰期为61±49分钟，而健康志愿者为26±8分钟（p<0.01）。我们未能在AIgG的半衰期与循环中的免疫复合物水平之间，或半衰期与关节疾病活动度（里奇指数）之间建立相关性。通过测定肝脏、脾脏和心脏可检测到的放射性水平，分析了AIgG从循环中清除的部位。半衰期与肝/脾摄取率之间未发现相关性。我们已经证明，RA患者循环中AIgG的清除是异常的，尽管这一发现的生物学意义仍有待确定。
