Halma C, Daha M R, Camps J A, Evers-Schouten J H, Pauwels E K, Van E s
Department of Nephrology, University Hospital Leiden, The Netherlands.
Clin Exp Immunol. 1992 Dec;90(3):394-400. doi: 10.1111/j.1365-2249.1992.tb05857.x.
Complement and erythrocyte complement receptors CR1 (CD35) play an important role in the clearance of immune complexes. We studied the elimination of soluble 123I-labelled aggregates of human immunoglobulin G (123I-AIgG), used as a model for immune complexes, in two patients with a congenital and two patients with an acquired deficiency of complement component C3, and compared these with 10 healthy controls. The first disappearance halflife of 123I-AIgG was shorter (3.3 +/- 0.4 versus 7.0 +/- 0.4 min in the controls, P = 0.005) and maximal hepatic uptake of aggregates was increased in the C3 deficient patients (maximal liver/background ratio 3.6 +/- 0.4 versus 2.7 +/- 0.2 in controls, P = 0.04). Apparently, in the absence of C3, removal of circulating immune complexes by the liver is accelerated, probably through Fc receptor-dependent mechanisms.
补体和红细胞补体受体CR1（CD35）在免疫复合物的清除中起重要作用。我们研究了以可溶性123I标记的人免疫球蛋白G聚集体（123I-AIgG）作为免疫复合物模型，在两名先天性和两名获得性补体成分C3缺乏患者体内的清除情况，并将其与10名健康对照者进行比较。123I-AIgG的首次消失半衰期较短（对照组为7.0±0.4分钟，患者组为3.3±0.4分钟，P = 0.005），C3缺乏患者体内聚集体的肝脏最大摄取量增加（肝脏最大摄取量与本底比值，对照组为2.7±0.2，患者组为3.6±0.4，P = 0.04）。显然，在缺乏C3的情况下，肝脏对循环免疫复合物的清除加速，可能是通过Fc受体依赖性机制实现的。
