Lv Guanglei, Sun Anyang, Wei Peng, Zhang Ning, Lan Haichuang, Yi Tao
Department of Chemistry and Collaborative Innovation Center of Chemistry for Energy Materials, Fudan University, Shanghai, 200433, P. R. China.
Laboratory of Neurodegenerative Diseases and Molecular Imaging, Shanghai University of Medicine & Health Sciences, Shanghai 201318, P. R. China.
Chem Commun (Camb). 2016 Jul 7;52(57):8865-8. doi: 10.1039/c6cc02741e.
We report a new spiropyran-based fluorescent probe that exhibits high affinity and specificity towards Aβ oligomers both in vitro and in vivo. This probe can penetrate the blood brain barrier and specifically target Aβ oligomers in the brains of transgenic mice in models for Alzheimer's disease.
我们报道了一种基于螺吡喃的新型荧光探针，该探针在体外和体内对β-淀粉样蛋白（Aβ）寡聚体均表现出高亲和力和特异性。这种探针能够穿透血脑屏障，并在阿尔茨海默病模型的转基因小鼠大脑中特异性靶向Aβ寡聚体。
