Gao Jisheng, Wu Hongwei, Liu Jinfeng
Department of Neonatology, Xuzhou Chlidren's Hospital, Xuzhou, Jiangsu 221002, P.R. China.
Exp Ther Med. 2016 Jul;12(1):28-32. doi: 10.3892/etm.2016.3253. Epub 2016 Apr 11.
The multifarious assortment of microorganisms present in gut of humans is termed as gut microbiota. These include 1,000 species accompanied by approximately 2 million genes in an individual adult. The gut microbiota has multifactorial protective roles against allergic reactions, inflammation, cardiac pathological states and even in the state of malignant carcinogenesis existing in humans. By contrast, adverse alterations in the microbiota result in chronic pathological states, including autoimmune diseases, cancer and circulatory system obstructions. Gut bacteria also maintain sensitivity towards nutritional changes as well as antibiotics. The present review article focused on the importance of gut bacteria in newborn infants with special reference to their protective role in various pediatric pathological states linked with gut bacteria. In addition, the importance of probiotics in relation to gut microbiota are to be discussed.
人类肠道中存在的各种各样的微生物被称为肠道微生物群。其中包括1000个物种,在一个成年个体中大约有200万个基因。肠道微生物群对人类的过敏反应、炎症、心脏病理状态甚至恶性致癌状态具有多因素保护作用。相比之下,微生物群的不良改变会导致慢性病理状态,包括自身免疫性疾病、癌症和循环系统阻塞。肠道细菌对营养变化和抗生素也保持敏感。本综述文章重点关注新生婴儿肠道细菌的重要性,特别提及它们在与肠道细菌相关的各种儿科病理状态中的保护作用。此外,还将讨论益生菌与肠道微生物群的关系。