Benmechernene Zineb, Fernandez-No Inmaculada, Kihal Mebrouk, Böhme Karola, Calo-Mata Pilar, Barros-Velazquez Jorge
Laboratory of Applied Microbiology, Department of Biology, Faculty of Sciences, Oran University, B.P. 16, Es-Senia, Oran, 31100 Algeria.
Recent Pat DNA Gene Seq. 2013 Apr 1;7(1):66-73. doi: 10.2174/1872215611307010010.
Most types of bacteria produce bacteriocins, which are proteinaceous extracellular compounds that can inhibit the growth of other undesirable microorganisms. Bacteriocins are receiving increasing attention, due to their many applications, ranging from their initial application in strategies for food preservation to more recent proposed uses in biomedical strategies aimed at fighting certain bacterial infections. Thus, while nisin has a long history of use as a safe additive in certain food products for the purpose of food preservation, certain bacteriocin-producing lactic acid bacteria, which are generally recognised as safe microorganisms, or their extracellular extracts are receiving increased attention as protective cultures or antimicrobial extracts in minimally processed food products. More recently, a number of these bacteriocinproducing cultures have been proposed for use in other applications, such as in probiotics, for the inhibition of biofilms in the food industry, or even as coadjuvants of combined therapeutical strategies along with other antimicrobial agents in biomedical applications. This review aims to provide a brief overview of the most relevant recent patents in this field.
大多数类型的细菌都会产生细菌素，细菌素是一种蛋白质类胞外化合物，能够抑制其他有害微生物的生长。由于细菌素具有诸多应用，从其最初在食品保鲜策略中的应用到最近在旨在对抗某些细菌感染的生物医学策略中的拟用，它正受到越来越多的关注。因此，尽管乳酸链球菌素作为一种安全添加剂在某些食品中用于食品保鲜已有很长历史，但某些产细菌素的乳酸菌（通常被认为是安全微生物）或其胞外提取物作为最低限度加工食品中的保护性培养物或抗菌提取物正受到越来越多的关注。最近，许多这些产细菌素的培养物已被提议用于其他应用，例如用于益生菌，抑制食品工业中的生物膜，甚至在生物医学应用中作为联合治疗策略的辅助剂与其他抗菌剂一起使用。本综述旨在简要概述该领域最近最相关的专利。
