State Key Laboratory for Modification of Chemical Fibers & Polymer Materials, College of Chemistry, Chemical Engineering & Biotechnology, Donghua University, Shanghai 201620, People's Republic of China.
Department of Radiology, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai 200072, People's Republic of China.
Nanomedicine (Lond). 2016 Jul;11(13):1639-52. doi: 10.2217/nnm-2016-0093. Epub 2016 Jun 27.
To synthesize and characterize cost-efficient polyethylenimine-entrapped gold nanoparticles loaded with gadolinium (Gd@Au PENPs) for dual-mode computed tomography (CT)/magnetic resonance (MR) imaging applications.
MATERIALS & METHODS: PEGylated PEI modified with gadolinium (Gd) chelator (DOTA) was used as a template to synthesize the Gd@Au PENPs and the particles were well characterized in terms of their physicochemical properties, cytotoxicity and performances in CT and MR imaging in vitro and in vivo.
The formed Gd@Au PENPs with low cytotoxicity can be used as a highly efficient contrast agent for dual-mode CT/MR imaging of blood pool and major organs of animals.
The designed Gd@Au PENPs may be used as a versatile nanoplatform for dual-mode CT/MR imaging of different biological systems.
合成并表征具有成本效益的负载钆的聚乙烯亚胺包埋金纳米粒子（Gd@Au PENPs），用于双模式计算机断层扫描（CT）/磁共振（MR）成像应用。
使用聚乙二醇化的聚乙烯亚胺（PEI）修饰物（DOTA）作为模板来合成 Gd@Au PENPs，并对其物理化学性质、体外和体内细胞毒性以及 CT 和 MR 成像性能进行了全面的表征。
形成的具有低细胞毒性的 Gd@Au PENPs 可用作动物血池和主要器官的双模式 CT/MR 成像的高效造影剂。
设计的 Gd@Au PENPs 可作为不同生物系统的双模式 CT/MR 成像的通用纳米平台。
