聚乙二醇化的聚乙烯亚胺包埋的载钆金纳米颗粒，用于双模 CT/MR 成像应用。
PEGylated polyethylenimine-entrapped gold nanoparticles loaded with gadolinium for dual-mode CT/MR imaging applications.
机构信息
State Key Laboratory for Modification of Chemical Fibers & Polymer Materials, College of Chemistry, Chemical Engineering & Biotechnology, Donghua University, Shanghai 201620, People's Republic of China.
Department of Radiology, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai 200072, People's Republic of China.
出版信息
Nanomedicine (Lond). 2016 Jul;11(13):1639-52. doi: 10.2217/nnm-2016-0093. Epub 2016 Jun 27.
AIM
To synthesize and characterize cost-efficient polyethylenimine-entrapped gold nanoparticles loaded with gadolinium (Gd@Au PENPs) for dual-mode computed tomography (CT)/magnetic resonance (MR) imaging applications.
MATERIALS & METHODS: PEGylated PEI modified with gadolinium (Gd) chelator (DOTA) was used as a template to synthesize the Gd@Au PENPs and the particles were well characterized in terms of their physicochemical properties, cytotoxicity and performances in CT and MR imaging in vitro and in vivo.
RESULTS
The formed Gd@Au PENPs with low cytotoxicity can be used as a highly efficient contrast agent for dual-mode CT/MR imaging of blood pool and major organs of animals.
CONCLUSION
The designed Gd@Au PENPs may be used as a versatile nanoplatform for dual-mode CT/MR imaging of different biological systems.
目的
合成并表征具有成本效益的负载钆的聚乙烯亚胺包埋金纳米粒子（Gd@Au PENPs），用于双模式计算机断层扫描（CT）/磁共振（MR）成像应用。
材料与方法
使用聚乙二醇化的聚乙烯亚胺（PEI）修饰物（DOTA）作为模板来合成 Gd@Au PENPs，并对其物理化学性质、体外和体内细胞毒性以及 CT 和 MR 成像性能进行了全面的表征。
结果
形成的具有低细胞毒性的 Gd@Au PENPs 可用作动物血池和主要器官的双模式 CT/MR 成像的高效造影剂。
结论
设计的 Gd@Au PENPs 可作为不同生物系统的双模式 CT/MR 成像的通用纳米平台。
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