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掺钆中空 CeO-ZrO 纳米平台作为多功能 MRI/CT 双模式成像剂和药物递送载体。

Gadolinium-doped hollow CeO-ZrO nanoplatform as multifunctional MRI/CT dual-modal imaging agent and drug delivery vehicle.

机构信息

a Liver Disease Center , the First Affiliated Hospital of Fujian Medical University , Fuzhou , P. R. China.

b The United Innovation of Mengchao Hepatobiliary Technology Key Laboratory of Fujian Province , Mengchao Hepatobiliary Hospital of Fujian Medical University , Fuzhou , P. R. China.

出版信息

Drug Deliv. 2018 Nov;25(1):353-363. doi: 10.1080/10717544.2018.1428241.

DOI:10.1080/10717544.2018.1428241
PMID:29366349
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6058605/
Abstract

Developing multifunctional nanoparticle-based theranostic platform for cancer diagnosis and treatment is highly desirable, however, most of the present theranostic platforms are fabricated via complicated structure/composition design and time-consuming synthesis procedures. Herein, the multifunctional Gd/CeO-ZrO/DOX-PEG nanoplatform with single nano-structure was fabricated through a facile route, which possessed MR/CT dual-model imaging and chemotherapy ability. The nanoplatform not only exhibited well-defined shapes, tunable compositions and narrow size distributions, but also presented a well anti-cancer effect and MR/CT imaging ability. Therefore, the Gd/CeO-ZrO/DOX-PEG nanoplatform could be applied for chemotherapy as well as dual-model MR/CT imaging.

摘要

开发用于癌症诊断和治疗的多功能基于纳米粒子的治疗诊断一体化平台是非常需要的，然而，大多数现有的治疗诊断一体化平台是通过复杂的结构/组成设计和耗时的合成步骤来制造的。在此，通过简便的路线制备了具有单纳米结构的多功能 Gd/CeO-ZrO/DOX-PEG 纳米平台，其具有磁共振/计算机断层扫描（CT）双模式成像和化疗能力。该纳米平台不仅具有明确的形状、可调的组成和窄的尺寸分布，而且还表现出良好的抗癌效果和磁共振/CT 成像能力。因此，Gd/CeO-ZrO/DOX-PEG 纳米平台可用于化疗以及磁共振/CT 双模式成像。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0d43/6058605/56a315b0ce33/IDRD_A_1428241_F0005_C.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0d43/6058605/23916eb6845a/IDRD_A_1428241_SCH0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0d43/6058605/8c4ef4ed5b6c/IDRD_A_1428241_F0001_C.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0d43/6058605/393c9f7239ca/IDRD_A_1428241_F0002_C.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0d43/6058605/2ab2c1294704/IDRD_A_1428241_F0003_C.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0d43/6058605/d155e24368e4/IDRD_A_1428241_F0004_C.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0d43/6058605/56a315b0ce33/IDRD_A_1428241_F0005_C.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0d43/6058605/23916eb6845a/IDRD_A_1428241_SCH0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0d43/6058605/8c4ef4ed5b6c/IDRD_A_1428241_F0001_C.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0d43/6058605/393c9f7239ca/IDRD_A_1428241_F0002_C.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0d43/6058605/2ab2c1294704/IDRD_A_1428241_F0003_C.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0d43/6058605/d155e24368e4/IDRD_A_1428241_F0004_C.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0d43/6058605/56a315b0ce33/IDRD_A_1428241_F0005_C.jpg

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