Gadolinium-doped hollow CeO-ZrO nanoplatform as multifunctional MRI/CT dual-modal imaging agent and drug delivery vehicle.

Developing multifunctional nanoparticle-based theranostic platform for cancer diagnosis and treatment is highly desirable, however, most of the present theranostic platforms are fabricated via complicated structure/composition design and time-consuming synthesis procedures. Herein, the multifunctional Gd/CeO-ZrO/DOX-PEG nanoplatform with single nano-structure was fabricated through a facile route, which possessed MR/CT dual-model imaging and chemotherapy ability. The nanoplatform not only exhibited well-defined shapes, tunable compositions and narrow size distributions, but also presented a well anti-cancer effect and MR/CT imaging ability. Therefore, the Gd/CeO-ZrO/DOX-PEG nanoplatform could be applied for chemotherapy as well as dual-model MR/CT imaging.