a Departamento de Inmunología, Escuela Nacional de Ciencias Biologicas, IPN , Prol. Carpio y Plan de Ayala , CDMéxico , México.
Infect Dis (Lond). 2016 Oct;48(10):715-20. doi: 10.1080/23744235.2016.1194529. Epub 2016 Jun 27.
Helminth parasites are a major cause of global infectious diseases, affecting nearly one quarter of the world's population. The common feature of helminth infections is to skew the immune system towards a T-helper 2 (Th2) response that helps to control disease. Dendritic cells (DCs), which are professional antigen-presenting cells, play a critical role for Th2 skewing against helminth parasites. However, the molecular mechanisms by which helminth antigens activate DCs for Th2 polarization have not yet been clearly defined. This review provides a focused update on the major role of DCs for inducing and/or enhancing Th2 immune responses in helminthic infection and will discuss the main signalling-dependent and independent mechanisms by which helminth antigens activate DCs for Th2 skewing.
寄生虫是全球传染病的主要病因，影响了近四分之一的世界人口。寄生虫感染的共同特征是使免疫系统向辅助性 T 细胞 2（Th2）反应倾斜，从而有助于控制疾病。树突状细胞（DCs）是专业的抗原呈递细胞，在针对寄生虫的 Th2 倾斜中发挥着关键作用。然而，寄生虫抗原激活 DC 以诱导 Th2 极化的分子机制尚未明确界定。本综述重点介绍了 DC 在诱导和/或增强寄生虫感染中的 Th2 免疫反应方面的主要作用，并讨论了寄生虫抗原激活 DC 以诱导 Th2 倾斜的主要信号依赖性和非依赖性机制。
