Zheng Kangdi, Wu Qiong, Wang Chengxi, Tan Weijun, Mei Wenjie
School of Food Science, Guangdong Pharmaceutical University, Zhongshan 528458, China.
Department of School of Pharmacy, Guangdong Pharmaceutical University, Guangzhou 510006, China.
Anticancer Agents Med Chem. 2017;17(1):29-39.
Herein, the development of ruthenium complexes as potential apoptosis inducers, as well as their underlying mechanism has been reviewed. In recent years, various ruthenium complexes have been designed and their in vitro and in vivo inhibitory activities against various types of tumor cells have been evaluated extensively. It's demonstrated that ruthenium complexes can induce apoptosis of tumor cells through the signal pathway of mitochondria-mediated, death receptor-mediated, and/or endoplasmic reticulum (ER) stress pathways. Alternately, the binding behavior of these ruthenium(II) complexes with DNA, especially with Gquadruplex DNA may play a key role in the DNA damage of tumor cells, and thus provides a versatile tool to rational design novel ruthenium complexes with high activity and selectivity.
本文综述了钌配合物作为潜在凋亡诱导剂的发展及其潜在机制。近年来，人们设计了各种钌配合物，并对其对各种类型肿瘤细胞的体外和体内抑制活性进行了广泛评估。结果表明，钌配合物可通过线粒体介导的信号通路、死亡受体介导的信号通路和/或内质网（ER）应激通路诱导肿瘤细胞凋亡。另外，这些钌（II）配合物与DNA，特别是与G-四链体DNA的结合行为可能在肿瘤细胞的DNA损伤中起关键作用，从而为合理设计具有高活性和选择性的新型钌配合物提供了一种通用工具。
