Ann Romney Center for Neurologic Diseases, Evergrande Center for Immunologic Diseases, Partners Multiple Sclerosis Center, Brigham and Women's Hospital, Department of Neurology, Harvard Medical School, Boston, Massachusetts 02115, USA.
Center for Clinical and Translational Metagenomics, Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA.
Nat Commun. 2016 Jun 28;7:12015. doi: 10.1038/ncomms12015.
The gut microbiome plays an important role in immune function and has been implicated in several autoimmune disorders. Here we use 16S rRNA sequencing to investigate the gut microbiome in subjects with multiple sclerosis (MS, n=60) and healthy controls (n=43). Microbiome alterations in MS include increases in Methanobrevibacter and Akkermansia and decreases in Butyricimonas, and correlate with variations in the expression of genes involved in dendritic cell maturation, interferon signalling and NF-kB signalling pathways in circulating T cells and monocytes. Patients on disease-modifying treatment show increased abundances of Prevotella and Sutterella, and decreased Sarcina, compared with untreated patients. MS patients of a second cohort show elevated breath methane compared with controls, consistent with our observation of increased gut Methanobrevibacter in MS in the first cohort. Further study is required to assess whether the observed alterations in the gut microbiome play a role in, or are a consequence of, MS pathogenesis.
肠道微生物组在免疫功能中发挥重要作用，并与几种自身免疫性疾病有关。在这里，我们使用 16S rRNA 测序来研究多发性硬化症（MS，n=60）患者和健康对照（n=43）的肠道微生物组。MS 中的微生物组改变包括甲烷杆菌和阿克曼氏菌的增加，丁酸单胞菌的减少，并且与循环 T 细胞和单核细胞中参与树突状细胞成熟、干扰素信号和 NF-κB 信号通路的基因表达的变化相关。与未接受治疗的患者相比，接受疾病修正治疗的患者中普雷沃氏菌和萨特氏菌的丰度增加，而 Sarcina 的丰度降低。与对照组相比，第二个队列的 MS 患者的呼气甲烷水平升高，与我们在第一个队列中观察到的 MS 中肠道甲烷杆菌增加一致。需要进一步研究以评估肠道微生物组的这些观察到的改变是否在 MS 发病机制中发挥作用，或者是否是其结果。
Zotero 插件
