Sabato Leah A, Mendes Lisa A, Cox Zachary L
1 Department of Pharmacy, Vanderbilt University Medical Center, Nashville, TN, USA.
2 Division of Cardiovascular Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.
J Pharm Pract. 2017 Oct;30(5):571-575. doi: 10.1177/0897190016655726. Epub 2016 Jun 26.
Hydroxychloroquine (HQ) is commonly prescribed for autoimmune diseases such as systemic lupus erythematosus. We report a case of a 75-year-old female presenting with de novo decompensated heart failure and restrictive cardiomyopathy (left ventricular ejection fraction: 40%-45%) after treatment with HQ for more than 11 years. Hydroxychloroquine was discontinued, and follow-up echocardiogram 57 days after discontinuation showed normalization of her left ventricular ejection fraction. A score of 7 on the Naranjo Adverse Drug Reaction Probability Scale indicates that HQ is a probable cause of this patient's cardiomyopathy. An adverse drug effect due to HQ should be considered in treated patients who present with restrictive cardiomyopathy. Discontinuation may allow for partial or complete reversal of the cardiomyopathy.
羟氯喹（HQ）常用于治疗自身免疫性疾病，如系统性红斑狼疮。我们报告了一例75岁女性病例，该患者在使用HQ治疗超过11年后出现了新发失代偿性心力衰竭和限制性心肌病（左心室射血分数：40%-45%）。停用羟氯喹后，停药57天的随访超声心动图显示其左心室射血分数恢复正常。Naranjo药物不良反应概率量表评分为7分，表明HQ很可能是该患者心肌病的病因。对于出现限制性心肌病的接受治疗患者，应考虑HQ引起的药物不良反应。停药可能使心肌病部分或完全逆转。
