Wichner Dominik, Idris Hamidah, Houssen Wael E, McEwan Andrew R, Bull Alan T, Asenjo Juan A, Goodfellow Michael, Jaspars Marcel, Ebel Rainer, Rateb Mostafa E
Marine Biodiscovery Centre, Department of Chemistry, University of Aberdeen, Scotland, UK.
Department of Chemistry, University of Regensburg, Universitätsstraße 31, Regensburg, Germany.
J Antibiot (Tokyo). 2017 Apr;70(4):448-453. doi: 10.1038/ja.2016.78. Epub 2016 Jun 29.
The extremotolerant isolate H45 was one of several actinomycetes isolated from a high-altitude Atacama Desert soil collected in northwest Chile. The isolate was identified as a new Lentzea sp. using a combination of chemotaxonomic, morphological and phylogenetic properties. Large scale fermentation of the strain in two different media followed by chromatographic purification led to the isolation of six new diene and monoene glycosides named lentzeosides A-F, together with the known compound (Z)-3-hexenyl glucoside. The structures of the new compounds were confirmed by HRESIMS and NMR analyses. Compounds 1-6 displayed moderate inhibitory activity against HIV integrase.
极端耐受菌株H45是从智利西北部采集的高海拔阿塔卡马沙漠土壤中分离出的几种放线菌之一。利用化学分类学、形态学和系统发育学特性相结合的方法，该菌株被鉴定为一个新的伦茨氏菌属（Lentzea sp.）。该菌株在两种不同培养基中进行大规模发酵，然后通过色谱纯化，分离出六种新的二烯和单烯糖苷，命名为伦茨糖苷A - F，以及已知化合物（Z）-3-己烯基葡萄糖苷。通过高分辨电喷雾电离质谱（HRESIMS）和核磁共振（NMR）分析确定了新化合物的结构。化合物1 - 6对HIV整合酶表现出中等抑制活性。
