来自海州常山的具有HIV-1整合酶抑制活性的苯丙素糖苷
HIV-1 integrase inhibitory phenylpropanoid glycosides from Clerodendron trichotomum.
作者信息
Kim H J, Woo E R, Shin C G, Hwang D J, Park H, Lee Y S
机构信息
Division of Life Sciences, Korea Institute of Science & Technology, Seoul.
出版信息
Arch Pharm Res. 2001 Aug;24(4):286-91. doi: 10.1007/BF02975093.
PMID:11534758
Abstract
Seven phenylpropanoid glycosides named acteoside (1), acteoside isomer (2), leucosceptoside A (3), plantainoside C (4), jionoside D (5), martynoside (6), and isomartynoside (7) were isolated from Clerodendron trichotomum. Compounds 1 and 2 showed potent inhibitory activities against HIV-1 integrase with IC50 values of 7.8 +/- 3.6 and 13.7 +/- 6.0 microM, respectively.
摘要
从三裂叶野海棠中分离出七种苯丙素苷，分别为毛蕊花糖苷（1）、毛蕊花糖苷异构体（2）、白花败酱苷A（3）、车前糖苷C（4）、紫花前胡苷D（5）、肉苁蓉苷（6）和异肉苁蓉苷（7）。化合物1和2对HIV-1整合酶显示出强效抑制活性，IC50值分别为7.8±3.6和13.7±6.0微摩尔。
Zotero 插件