Yu Bo, Wang Cun-Yu
Department of Oral Biology and Oral Medicine, School of Dentistry, University of California, Los Angeles, CA 90095, USA.
Department of Oral Biology and Oral Medicine, School of Dentistry, University of California, Los Angeles, CA 90095, USA; Department of Bioengineering, Henry Samueli School of Engineering and Applied Science, Jonsson Comprehensive Cancer Center, Broad Stem Cell Research Institute, University of California, Los Angeles, CA 90095, USA.
Trends Mol Med. 2016 Aug;22(8):641-644. doi: 10.1016/j.molmed.2016.06.002. Epub 2016 Jun 26.
Osteoporosis is an age-related progressive bone disease. Recent advances in epigenetics, cell biology, osteoimmunology, and genetic epidemiology have unraveled new mechanisms and players underlying the pathology of osteoporosis, supporting a model of age-related dysregulation and crosstalk in the bone microenvironment.
骨质疏松症是一种与年龄相关的进行性骨病。表观遗传学、细胞生物学、骨免疫学和遗传流行病学的最新进展揭示了骨质疏松症病理背后的新机制和相关因素,支持了骨微环境中与年龄相关的失调和相互作用模型。