Department of Rheumatology & Clinical Immunology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, the Ministry of Education Key Laboratory, Beijing, 100730, China.
Department of Rheumatology, the First People's Hospital of Yueyang, Yueyang, 414000, China.
Sci China Life Sci. 2016 Dec;59(12):1241-1258. doi: 10.1007/s11427-016-5105-7. Epub 2016 Sep 20.
Rapid progress has been made in exploring the connections between the skeletal system and the immune system over the past decade. Bone tissue forms developmental niches for hematopoietic stem cells, and activated immune cells are involved in bone metabolism regulation and are potent mediators of osteoporosis and bone erosion under pathological conditions. The interdisciplinary field of osteoimmunology has emerged to pool the knowledge of the interdependence of these two systems, including the shared ligands and receptors, their crosstalk and interaction, and common intracellular signaling pathways with bidirectional influence. The receptor activator of nuclear factor-kappa B (RANK)/RANK ligand (RANKL)/osteoprotegerin (OPG) triad is the key vinculum, with multifaceted potency, being not only essential for osteoclastogenesis but also critical for lymph node organogenesis and lymphopoiesis as well as for immune regulation. In this review, we summarize the progress in this area, focusing on those aspects of interest concerning rheumatic diseases.
在过去的十年中，人们在探索骨骼系统和免疫系统之间的联系方面取得了快速进展。骨组织为造血干细胞形成发育龛，激活的免疫细胞参与骨代谢调节，并在病理条件下成为骨质疏松症和骨质侵蚀的有力介质。骨免疫学这一交叉学科领域汇集了这两个系统相互依存的知识，包括共享的配体和受体、它们的串扰和相互作用以及具有双向影响的共同细胞内信号通路。核因子-κB 受体激活剂（RANK）/RANK 配体（RANKL）/骨保护素（OPG）三联体是关键的连接物，具有多方面的功能，不仅对破骨细胞形成至关重要，而且对淋巴结发生和淋巴生成以及免疫调节也至关重要。在这篇综述中，我们总结了这一领域的进展，重点关注与风湿性疾病有关的方面。
