淀粉样前体蛋白在成体经验依赖性可塑性中的生理作用。
Physiological role for amyloid precursor protein in adult experience-dependent plasticity.
作者信息
Marik Sally A, Olsen Olav, Tessier-Lavigne Marc, Gilbert Charles D
机构信息
Laboratory of Neurobiology, The Rockefeller University, New York, NY 10065;
Laboratory of Brain Development and Repair, The Rockefeller University, New York, NY 10065.
出版信息
Proc Natl Acad Sci U S A. 2016 Jul 12;113(28):7912-7. doi: 10.1073/pnas.1604299113. Epub 2016 Jun 27.
Abstract
Changes in neural circuits after experience-dependent plasticity are brought about by the formation of new circuits via axonal growth and pruning. Here, using a combination of electrophysiology, adeno-associated virus-delivered fluorescent proteins, analysis of mutant mice, and two-photon microscopy, we follow long-range horizontally projecting axons in primary somatosensory cortex before and after selective whisker plucking. Whisker plucking induces axonal growth and pruning of horizontal projecting axons from neurons located in the surrounding intact whisker representations. We report that amyloid precursor protein is crucial for axonal pruning and contributes in a cell autonomous way.
摘要
经验依赖性可塑性之后神经回路的变化是通过轴突生长和修剪形成新的回路来实现的。在这里，我们结合电生理学、腺相关病毒递送的荧光蛋白、突变小鼠分析和双光子显微镜技术，追踪了选择性拔毛前后初级体感皮层中长距离水平投射轴突的情况。拔毛诱导了来自周围完整触须表征区域神经元的水平投射轴突的轴突生长和修剪。我们报告称，淀粉样前体蛋白对轴突修剪至关重要，并以细胞自主的方式发挥作用。
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