Frosina Guido
Mutagenesis Unit, IRCCS AOU San Martino - IST, Genoa, Italy
Anticancer Res. 2016 Jul;36(7):3253-60.
Thorough imaging is crucial for diagnosis and treatment of high-grade gliomas (HGG), lethal brain tumours with median survival ranging 1-5 years after diagnosis. Positron-emission tomography (PET) is acquiring importance in imaging of HGG since it has the formidable advantage of providing information on tumour metabolism that may be critical for correct diagnosis and treatment planning. Recently employed PET tracers designed for the non-routine investigation of specific aspects of HGG metabolism, including hypoxia, neoangiogenesis, expression of integrins and stem cell markers, are reviewed herein. A thorough choice from among these non-routine tracers may provide important metabolic information complementing those obtained with more common PET analyses, for the sake of diagnostic, prognostic, treatment planning or research purposes.
全面的影像学检查对于高级别胶质瘤（HGG）的诊断和治疗至关重要，HGG是一种致命的脑肿瘤，诊断后的中位生存期为1至5年。正电子发射断层扫描（PET）在HGG的影像学检查中越来越重要，因为它具有提供肿瘤代谢信息的巨大优势，这对于正确的诊断和治疗规划可能至关重要。本文综述了最近用于HGG代谢特定方面非常规研究的PET示踪剂，包括缺氧、新生血管形成、整合素和干细胞标志物的表达。从这些非常规示踪剂中进行全面选择，可为诊断、预后、治疗规划或研究目的提供补充更常见PET分析所获得信息的重要代谢信息。
